Evidence map›Paper›PMID 29936482›Full record

ArticleIn vivo (Athens, Greece)

Relationship Between p16 Expression and Prognosis in Patients with Oropharyngeal Cancer Undergoing Surgery.

Kota Kida, Tomonori Terada, Nobuhiro Uwa, Yoshihiko Omori, Takashi Fujii, Yasuhiko Tomita, Kenzo Tsuzuki, Hiroki Nishikawa, Masafumi Sakagami

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PubMed Full text at PMC Publisher

In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it

0cells of the map it votes in

5citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

Transnasal Endoscopic Resection of a Pituitary Metastasis From a Tonsillar Squamous Cell Carcinoma (SCC): A Case Report and a Review of the Literature.Cureus · 2025
Article
HPV infection and 5mC/5hmC epigenetic markers in penile squamous cell carcinoma: new insights into prognostics.Clinical epigenetics · 2022
Article
Non-Robustness of Ang's Risk Classification in Human Papillomavirus-Related Oropharyngeal Squamous Cell Carcinoma in Japanese Patients.Cancers · 2022
Article
Immunohistochemical Expressions of Senescence-Associated Secretory Phenotype and Its Association With Immune Microenvironments and Clinicopathological Factors in Invasive Breast Cancer.Pathology oncology research : POR · 2021
Article
Visualization of mucosal field in HPV positive and negative oropharyngeal squamous cell carcinomas: combined genomic and radiology based 3D model.Scientific reports · 2020
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kota KidaDepartment of Otolaryngology-Head and Neck Surgery, Hyogo College of Medicine, Hyogo, Japan kotakida@hyo-med.ac.jp.

Tomonori TeradaDepartment of Otolaryngology-Head and Neck Surgery, Hyogo College of Medicine, Hyogo, Japan.

Nobuhiro UwaDepartment of Otolaryngology-Head and Neck Surgery, Hyogo College of Medicine, Hyogo, Japan.

Yoshihiko OmoriDepartment of Otolaryngology-Head and Neck Surgery, Hyogo College of Medicine, Hyogo, Japan.

Takashi FujiiDepartment of Head and Neck Surgery, Osaka International Cancer Institute, Osaka, Japan.

Yasuhiko TomitaDepartment of Pathology Diagnosis, International University of Health and Welfare, Tokyo, Japan.

Kenzo TsuzukiDepartment of Otolaryngology-Head and Neck Surgery, Hyogo College of Medicine, Hyogo, Japan.

Hiroki NishikawaCenter for Clinical Research and Education, Hyogo College of Medicine, Hyogo, Japan.

Masafumi SakagamiDepartment of Otolaryngology-Head and Neck Surgery, Hyogo College of Medicine, Hyogo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimPrognostic impact of p16 expression in patients with oropharyngeal squamous cell carcinoma (OSCC) undergoing surgery is not fully examined. The aim of this study was to clarify these issues. PATIENTS AND

methodsSixty-four OSCC subjects were analyzed. Immuno-histochemical staining of p16, a surrogate marker for human papillomavirus (HPV), was performed histopathologically. Data were retrospectively analyzed according to p16 positivity and factors linked to prognosis were also analyzed.

resultsNo significant difference was observed in the prognosis between the p16-positive group (n=28) and the p16-negative group (n=36). In patients undergoing post-operative radiation, the p16-positive group (n=18) had a significantly better prognosis than the p16-negative group (n=6). On multivariate analysis, transoral surgery was a significant predictor of overall survival (p=0.0173).

conclusionPrognostic impact of p16 can be emphasized in a subgroup of OSCC patients undergoing surgery. Surgery with sufficient surgical margin may be chosen as the first treatment for HPV-negative OSCC in some cases.

Indexed as

AdultAgedCyclin-Dependent Kinase Inhibitor p16FemaleGene Expression Regulation, NeoplasticHuman papillomavirus 16HumansMaleMiddle AgedOropharyngeal NeoplasmsPapillomavirus InfectionsPrognosisCDKN2A protein, humanCyclin-Dependent Kinase Inhibitor p16clinical outcomeHuman papillomavirusOropharyngeal cancerp16surgery

Identifiers

PMID29936482

DOI10.21873/invivo.11331

PMCPMC6117767

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.