ArticlePsychoneuroendocrinology2018
HIV and symptoms of depression are independently associated with impaired glucocorticoid signaling.
Article in Psychoneuroendocrinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 19 citations in OpenAlex.
- Examining Depression as a Risk Factor for Cardiovascular Disease in People with HIV: A Systematic Review.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2023Pooled it
- Systematic review of sex differences in the relationship between hormones and depression in HIV.Psychoneuroendocrinology · 2022Pooled it
- Sex Differences in Neurocognitive Function in Adults with HIV: Patterns, Predictors, and Mechanisms.Current psychiatry reports · 2019Pooled it
- Remitted depression and cognition in HIV: The role of cortisol and inflammation.Psychoneuroendocrinology · 2020Trial
- Association Between Alcohol Use, CD4 Count, and Depressive Symptoms Among People with HIV with Viral Load Suppressed in Southwestern Uganda.AIDS and behavior · 2026Article
- Cumulative burden of depression and domain-specific cognitive impairment over time in the women's interagency HIV study: A marginal structural model approach.Journal of affective disorders · 2026Article
- The impact of childhood maltreatment, HIV status, and their interaction on mental health outcomes and markers of systemic inflammation in women.Biology of sex differences · 2025Article
- Bidirectional Relationship between HIV/HBV Infection and Comorbid Depression and/or Anxiety: A Systematic Review on Shared Biological Mechanisms.Journal of personalized medicine · 2023Review
- Role of FKBP5 and its genetic mutations in stress-induced psychiatric disorders: an opportunity for drug discovery.Frontiers in psychiatry · 2023Review
- Neuroinflammation in HIV-associated depression: evidence and future perspectives.Molecular psychiatry · 2022Review
- Allopregnanolone and neuroHIV: Potential benefits of neuroendocrine modulation in the era of antiretroviral therapy.Journal of neuroendocrinology · 2022Review
- Unbiased Metabolomics Links Fatty Acid Pathways to Psychiatric Symptoms in People Living with HIV.Journal of clinical medicine · 2021Article
- Article
- HIV-1 Tat Dysregulates the Hypothalamic-Pituitary-Adrenal Stress Axis and Potentiates Oxycodone-Mediated Psychomotor and Anxiety-Like Behavior of Male Mice.International journal of molecular sciences · 2020Article
- Higher levels of plasma inflammation biomarkers are associated with depressed mood and quality of life in aging, virally suppressed men, but not women, with HIV.Brain, behavior, & immunity - health · 2020Article
Corrections and comments
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Authors and funding
20 authors at 11 institutions in 1 country.
Funding
Abstract
Chronic inflammation caused by HIV infection may lead to deficient glucocorticoid (GC) signaling predisposing people living with HIV to depression and other psychiatric disorders linked to GC resistance. We hypothesized that comorbid HIV and depressive symptoms in women would synergistically associate with deficits in GC signaling. This cross-sectional study used samples obtained from the Women's Interagency HIV Study (WIHS). The Centers for Epidemiological Studies (CES-D) was used to define depression in four groups of women from the Women's Interagency HIV Study (WIHS): 1) HIV-negative, non-depressed (n = 37); 2) HIV-negative, depressed (n = 34); 3) HIV-positive, non-depressed (n = 38); and 4) HIV-positive, depressed (n = 38). To assess changes in GC signaling from peripheral blood mononuclear cells (PBMCs), we examined baseline and dexamethasone (Dex)-stimulated changes in the expression of the GC receptor (GR, gene: Nr3c1) and its negative regulator Fkbp5 via quantitative RT-PCR. GR sensitivity was evaluated in vitro by assessing the Dex inhibition of lipopolysaccharide (LPS)-stimulated IL-6 and TNF-α levels. Depressive symptoms and HIV serostatus were independently associated with elevated baseline expression of Fkbp5 and Nr3c1. Depressive symptoms, but not HIV status, was independently associated with reduced LPS-induced release of IL-6. Counter to predictions, there was no interactive association of depressive symptoms and HIV on any outcome. Comorbid depressive symptoms with HIV infection were associated with a gene expression and cytokine profile similar to that of healthy control women, a finding that may indicate further disruptions in disease adaptation.
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Registered trials
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