ReviewNeurobiology of disease2019
The neurobiological effects of repetitive head impacts in collision sports.
Review in Neurobiology of disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Unlocking the Impact: A Systematic Review and Meta-Analysis of Biomechanical Insights into Rugby Head Impacts Using Wearable Sensor Technology.Sports medicine (Auckland, N.Z.) · 2025Pooled it
- A Systematic Review of Head Impacts and Acceleration Associated with Soccer.International journal of environmental research and public health · 2022Pooled it
- Head Impact Research Using Inertial Sensors in Sport: A Systematic Review of Methods, Demographics, and Factors Contributing to Exposure.Sports medicine (Auckland, N.Z.) · 2022Pooled it
- Biological Markers of Cognitive Impairments in Combat and Contact-Sport Athletes: A Systematic Review.Sports (Basel, Switzerland) · 2026Review
- Sex, but not exposure-related variables, predicts baseline serum glial fibrillar acidic protein and neurofilament light levels in contact sport athletes.BMJ open sport & exercise medicine · 2026Article
- Circulating oligodendrocyte-derived extracellular vesicle surface markers in athletes exposed to repetitive head impacts: an exploratory study.Frontiers in neurology · 2026Article
- Annual level changes of serum neuronal and glial biomarkers in a German professional football club.Journal of neurology · 2025Article
- Youth Soccer Heading Exposure and Its Effects on Clinical Outcome Measures.Sports (Basel, Switzerland) · 2024Article
- Anisotropy component of DTI reveals long-term neuroinflammation following repetitive mild traumatic brain injury in rats.European radiology experimental · 2024Article
- Levels of biomarkers associated with subconcussive head hits in mixed martial arts fighters.PeerJ · 2024Article
- Quantifying the Magnitude and Longevity of the Effect of Repetitive Head Impacts in Adolescent Soccer Players: Deleterious Effect of Long Headers Extend Beyond a Month.Neurotrauma reports · 2023Article
- Repetitive soccer heading adversely impacts short-term learning among adult women.Journal of science and medicine in sport · 2022Article
- Localized, time-dependent responses of rat cranial bone to repeated mild traumatic brain injuries.Scientific reports · 2022Article
- Understanding and Managing Trauma-Induced Vestibular Deficits.The journal of international advanced otology · 2021Review
- Head Impact Situations in Professional Football (Soccer).Sports medicine international open · 2021Article
- Purposeful Heading in Youth Soccer: A Review.Sports medicine (Auckland, N.Z.) · 2021Review
- A Novel Approach to Assessment of Perceptual-Motor Efficiency and Training-Induced Improvement in the Performance Capabilities of Elite Athletes.Frontiers in sports and active living · 2021Article
- Using Oculomotor Features to Predict Changes in Optic Nerve Sheath Diameter and ImPACT Scores From Contact-Sport Athletes.Frontiers in neurology · 2021Article
- Vision care in concussion and traumatic brain injury: unmet needs.Concussion (London, England) · 2020Article
- Concussion History and Neuromechanical Responsiveness Asymmetry.Journal of athletic training · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
It is now recognized that repetitive head impacts (RHI) in sport have the potential for long-term neurological impairments. In order to identify targets for intervention and/or pharmacological treatment, it is necessary to characterize the neurobiological mechanisms associated with RHI. This review aims to summarize animal and human studies that specifically address Blood Brain Barrier (BBB) dysfunction, abnormal neuro-metabolic and neuro-inflammatory processes as well as Tau aggregation associated with RHI in collision sports. Additionally, we examine the influence of physical activity and genetics on outcomes of RHI, discuss methodological considerations, and provide suggestions for future directions of this burgeoning area of research.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.