ArticleJournal of diabetes and its complications2018
Prevalence of arterial stiffness in adolescents with type 2 diabetes in the TODAY cohort: Relationships to glycemic control and other risk factors.
Article in Journal of diabetes and its complications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT00081328. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Studies to Treat Or Prevent Pediatric Type 2 Diabetes (STOPP-T2D) Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) Clinical Trial
Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- Impact of youth onset type 2 diabetes during pregnancy on microvascular and cardiac outcomes.Diabetes research and clinical practice · 2023Trial
- Heart Rate Variability and Cardiac Autonomic Dysfunction: Prevalence, Risk Factors, and Relationship to Arterial Stiffness in the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) Study.Diabetes care · 2019 · on this mapTrial
- Is There a Role for Imaging Youth at Risk of Atherosclerosis?Current atherosclerosis reports · 2023Review
- Type 2 diabetes in youth: Rationale for use of off-label antidiabetic agents.Pediatric diabetes · 2022Article
- Longitudinal Changes in Arterial Stiffness and Heart Rate Variability in Youth-Onset Type 1 Versus Type 2 Diabetes: The SEARCH for Diabetes in Youth Study.Diabetes care · 2022Article
- Relationship between Arterial Stiffness and Subsequent Cardiac Structure and Function in Young Adults with Youth-Onset Type 2 Diabetes: Results from the TODAY Study.Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2022Article
- Cardiovascular risk factor progression in adolescents and young adults with youth-onset type 2 diabetes.Journal of diabetes and its complications · 2022Article
- Spectrum of Phenotypes and Causes of Type 2 Diabetes in Children.Annual review of medicine · 2022Review
- Effect of glycemic control on markers of subclinical atherosclerosis in patients with type 2 diabetes mellitus: A review.World journal of diabetes · 2021Review
- Arterial Stiffness in Type 1 Diabetes: The Case for the Arterial Wall Itself as a Target Organ.Journal of clinical medicine · 2021Review
- Study protocol: a prospective controlled clinical trial to assess surgical or medical treatment for paediatric type 2 diabetes (STBMJ open · 2021Article
- Youth-onset type 2 diabetes: translating epidemiology into clinical trials.Diabetologia · 2021Review
- Racial differences of early vascular aging in children and adolescents.Pediatric nephrology (Berlin, Germany) · 2021Review
- Cardiovascular risk and heart rate variability in young adults with type 2 diabetes and arterial stiffness: The SEARCH for Diabetes in Youth Study.Journal of diabetes and its complications · 2020Article
- Mechanistic Causes of Reduced Cardiorespiratory Fitness in Type 2 Diabetes.Journal of the Endocrine Society · 2020Review
- The changing face of paediatric diabetes.Diabetologia · 2020Review
- Metabolic outcomes of surgery in youth with type 2 diabetes.Seminars in pediatric surgery · 2020Review
- Type 2 Diabetes in Youth.Global pediatric health · 2020Review
- Progress in understanding youth-onset type 2 diabetes in the United States: recent lessons from clinical trials.World journal of pediatrics : WJP · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 9 institutions in 1 country.
Funding
Abstract
aimsWe aimed to determine the prevalence of arterial stiffness in young adults with youth-onset type 2 diabetes who previously participated in the TODAY clinical trial and whether arterial stiffness is influenced by their prior diabetes treatment assignment or glycemic control.
methodsWe measured arterial stiffness by femoral, radial, and foot pulse wave velocity (PWV), augmentation index (AIx), and brachial distensibility (BrachD) in 453 TODAY participants (age 20.8 ± 2.5 years, diabetes duration 7.6 ± 1.5 years, 36.4% male, BMI 36.7 ± 8.2 kg/m
resultsArterial stiffness was identified in up to 50% of TODAY participants. Prior diabetes treatment assignment was not associated with higher arterial stiffness. Glycemic control over time was associated with PWV radial and foot only. Age, race-ethnicity, sex, higher blood pressure and BMI were also associated with higher arterial stiffness.
conclusionsNearly half of TODAY youth have increased arterial stiffness. Targeting blood pressure and perhaps obesity and glycemic control may positively impact arterial health in adolescents with type 2 diabetes.
trial registrationClinicalTrials.govNCT00081328.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.