Evidence map›Paper›PMID 29936038›Full record

ArticleInfection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases2018

Genetic diversity of the Plasmodium vivax multidrug resistance 1 gene in Thai parasite populations.

Veerayuth Kittichai, Wang Nguitragool, Huguette Gaelle Ngassa Mbenda, Jetsumon Sattabongkot, Liwang Cui

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Genetic diversity and molecular evolution of Plasmodium vivax Duffy Binding Protein and Merozoite Surface Protein-1 in northwestern Thailand.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2023
    Article
  3. Article
  4. The activity of methylene blue against asexual and sexual stages ofFrontiers in cellular and infection microbiology · 2023
    Article
  5. Article
  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Veerayuth KittichaiMahidol Vivax Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Faculty of Medicine, King Mongkut's Institute of Technology Ladkrabang, Bangkok, Thailand.
Wang NguitragoolDepartment of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Huguette Gaelle Ngassa MbendaDepartment of Entomology, Center for Malaria Research, Pennsylvania State University, University Park, PA, USA.
Jetsumon SattabongkotMahidol Vivax Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. Electronic address: jetsumon.pra@mahidol.ac.th.
Liwang CuiDepartment of Entomology, Center for Malaria Research, Pennsylvania State University, University Park, PA, USA. Electronic address: luc2@psu.edu.
Mahidol University · THPennsylvania State University · USMahidol Oxford Tropical Medicine Research Unit · TH

Funding

Southeast Asia Malaria Research CenterU19AI089672 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI CUI, LIWANG · 2010 to 2023
$28.9M
Vivax Malaria culture technique and genetic diversity in ThailandD43TW006571 · FIC · PENNSYLVANIA STATE UNIVERSITY-UNIV PARK · PI CUI, LIWANG · 2004 to 2018
$1.9M
FIC NIH HHS D43 TW006571NIAID NIH HHS U19 AI089672
6 · The paper itself

Abstract

Plasmodium vivax resistance to chloroquine (CQ) was first reported over 60 years ago. Here we analyzed sequence variations in the multidrug resistance 1 gene (Pvmdr1), a putative molecular marker for P. vivax CQ resistance, in field isolates collected from three sites in Thailand during 2013-2016. Several single nucleotide polymorphisms previously implicated in reduced CQ sensitivity were found. These genetic variations encode amino acids in the two nucleotide-binding domains as well as the transmembrane domains of the protein. The high level of genetic diversity of Pvmdr1 provides insights into the evolutionary history of this gene. Specifically, there was little evidence of positive selection at amino acid F1076L in global isolates to be promoted as a possible marker for CQ resistance. Population genetic analysis clearly divided the parasites into eastern and western populations, which is consistent with their geographical separation by the central malaria-free area of Thailand. With CQ-primaquine remaining as the frontline treatment for vivax malaria in all regions of Thailand, such a population subdivision could be shaped and affected by the current drugs for P. falciparum since mixed P. falciparum/P. vivax infections often occur in this region.

Indexed as

Genetic VariationAntimalarialsATP-Binding Cassette, Sub-Family C ProteinsDrug ResistanceGenetics, PopulationGenotypeHaplotypesHumansLinkage DisequilibriumMalaria, VivaxMonte Carlo MethodParasitic Sensitivity TestsPhylogenyPlasmodium vivaxPolymorphism, GeneticProtozoan ProteinsAntimalarialsATP-Binding Cassette, Sub-Family C ProteinsMdr1 protein, Plasmodium vivaxProtozoan ProteinsGenetic diversityGenetic structureMultidrug resistance 1 genePhylogenetic relationshipPlasmodium vivax

Identifiers

PMID29936038
PMCPMC6420305
OpenAlexW2809597101

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.