ArticleBritish journal of anaesthesia2018
A stochastic basis for neural inertia in emergence from general anaesthesia.
Article in British journal of anaesthesia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 40 citations in OpenAlex.
- Breathe-squeeze: pharmacodynamics of a stimulus-free behavioural paradigm to track conscious states during sedationBritish journal of anaesthesia · 2023Trial
- Revisiting MAC as a static measure of anaesthesia: evidence for dynamic responses under isoflurane in male mice.British journal of anaesthesia · 2026Article
- Early reactivation of medial temporal lobe neurons during emergence from propofol anesthesia in neurosurgical patients.bioRxiv : the preprint server for biology · 2026Article
- Subcortical recruitment dissociates isoflurane emergence from distinct wakeful states in mice.bioRxiv : the preprint server for biology · 2026Article
- Reanimation of rodents: an animal model for cognitive recovery from anaesthesia.British journal of anaesthesia · 2025Article
- A probabilistic model of behavioural emergence from general anaesthesia in mice.British journal of anaesthesia · 2025Article
- Anesthesia alters complexity of spontaneous and stimulus-related neuronal firing patterns in rat visual cortex.Neuroscience · 2025Article
- Linear thinking does not reflect the newer 21st-century anesthesia concepts. A narrative review.Journal of clinical monitoring and computing · 2023Review
- Computational modelling in disorders of consciousness: Closing the gap towards personalised models for restoring consciousness.NeuroImage · 2023Article
- Measures of Information Content during Anesthesia and Emergence in the Caenorhabditis elegans Nervous System.Anesthesiology · 2023Article
- Article
- Mechanisms Underlying Disorders of Consciousness: Bridging Gaps to Move Toward an Integrated Translational Science.Neurocritical care · 2021Article
- The Inert Brain: Explaining Neural Inertia as Post-anaesthetic Sleep Inertia.Frontiers in neuroscience · 2021Article
- Electroencephalographic Evidence for Individual Neural Inertia in Mice That Decreases With Time.Frontiers in systems neuroscience · 2021Article
- Explaining anaesthetic hysteresis with effect-site equilibration.British journal of anaesthesia · 2021Article
- Resistance to state transitions in responsiveness is differentially modulated by different volatile anaesthetics in male mice.British journal of anaesthesia · 2020Article
- Neural signatures of α2-Adrenergic agonist-induced unconsciousness and awakening by antagonist.eLife · 2020Article
- Neural Inertia: A Sticky Situation for Anesthesia.Journal of neurosurgical anesthesiology · 2020Article
- Desflurane Anesthesia Alters Cortical Layer-specific Hierarchical Interactions in Rat Cerebral Cortex.Anesthesiology · 2020Article
- Dynamics of recovery from anaesthesia-induced unconsciousness across primate neocortex.Brain : a journal of neurology · 2020Article
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2 authors at 2 institutions in 1 country.
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Abstract
backgroundTransitions into and out of the anaesthetised state exhibit resistance to state transitions known as neural inertia. As a consequence, emergence from anaesthesia occurs at a consistently lower anaesthetic concentration than induction. Motivated by stochastic switching between discrete activity patterns observed at constant anaesthetic concentration, we investigated the consequences of such switching for neural inertia.
methodsWe simulated stochastic switching in MATLAB as Brownian motion on an energy landscape or equivalently as a discrete Markov process. Effects of anaesthetics were modelled as changing stability of the awake and the anaesthetised states. Simulation results were compared with re-analysed neural inertia data from mice and Drosophila.
resultsDiffusion on a two-well energy landscape gives rise to hysteresis. With additive noise, hysteresis collapses. This collapse occurs over a mixing time that is independent from pharmacokinetics. The two-well potential gives rise to the leftward shift for the emergence dose-response curve. Yet, from in vivo data, ΔEC
conclusionsStochastic state switching accounts for all known features of neural inertia. More than two states are required to explain the consistent increase observed in variability of recovery from general anaesthesia. This model predicts that hysteresis should collapse with a time scale independent of anaesthetic drug pharmacokinetics.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.