ArticleBritish journal of anaesthesia2018
Opioid analgesia and the somatosensory memory of neonatal surgical injury in the adult rat.
Article in British journal of anaesthesia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Long-term impact of necrotizing enterocolitis on somatosensory function in preterm born children.Pediatric research · 2026Article
- Early Life Injury Alters Spinal Astrocyte Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- PRG-1 Relieves Neonatal Stimuli-Induced Hyperalgesia and Anxiety via Stage-Specific Synapse Remodeling.CNS neuroscience & therapeutics · 2025Article
- A Review of Chronic Wounds and Their Impact on Negative Affect, Cognition, and Quality of Life.International wound journal · 2025Review
- Modulating AMPA receptor-dependent synaptic plasticity: Mechanistic interventions against remifentanil-induced hyperalgesia in reoperative rats - A randomised controlled trial.Indian journal of anaesthesia · 2025Article
- Macrophage memories of early-life injury drive neonatal nociceptive priming.Cell reports · 2024Article
- Developmental impact of peripheral injury on neuroimmune signaling.Brain, behavior, and immunity · 2023Review
- Stress-induced changes in nociceptive responding post-surgery in preclinical rodent models.Frontiers in pain research (Lausanne, Switzerland) · 2022Review
- Genetic and epigenetic mechanisms influencing acute to chronic postsurgical pain transitions in pediatrics: Preclinical to clinical evidence.Canadian journal of pain = Revue canadienne de la douleur · 2022Review
- Developmental mechanisms of CPSP: Clinical observations and translational laboratory evaluations.Canadian journal of pain = Revue canadienne de la douleur · 2022Review
- Identifying the Neurodevelopmental Differences of Opioid Withdrawal.Cellular and molecular neurobiology · 2021Article
- Early Life Nociception is Influenced by Peripheral Growth Hormone Signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Methadone effectively attenuates acute and long-term consequences of neonatal repetitive procedural pain in a rat model.Pediatric research · 2021Article
- Neonatal Injury Evokes Persistent Deficits in Dynorphin Inhibitory Circuits within the Adult Mouse Superficial Dorsal Horn.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- The development of pain circuits and unique effects of neonatal injury.Journal of neural transmission (Vienna, Austria : 1996) · 2020Review
- Early Neonatal Pain-A Review of Clinical and Experimental Implications on Painful Conditions Later in Life.Frontiers in pediatrics · 2020Review
- Systemic growth hormone deficiency causes mechanical and thermal hypersensitivity during early postnatal development.IBRO reports · 2019Article
- Priming of Adult Incision Response by Early-Life Injury: Neonatal Microglial Inhibition Has Persistent But Sexually Dimorphic Effects in Adult Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Somatosensory function and pain in extremely preterm young adults from the UK EPICure cohort: sex-dependent differences and impact of neonatal surgery.British journal of anaesthesia · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundNociceptive input during early development can produce somatosensory memory that influences future pain response. Hind-paw incision during the 1st postnatal week in the rat enhances re-incision hyperalgesia in adulthood. We now evaluate its modulation by neonatal analgesia.
methodsNeonatal rats [Postnatal Day 3 (P3)] received saline, intrathecal morphine 0.1 mg kg-1 (IT), subcutaneous morphine 1 mg kg
resultsAdult re-incision hyperalgesia was not prevented by neonatal peri-incision morphine (saline, IT, and SC groups > IN; P<0.05-0.01). Neonatal sciatic block, but not morphine, prevented the enhanced re-incision reflex sensitivity in adulthood (LA < saline and morphine groups, P<0.01; LA vs IN, not significant). Morphine efficacy in adulthood was altered after morphine alone in the neonatal period, but not when administered with neonatal incision. Morphine prevented the acute incision-induced hyperalgesia in neonatal rats, but only sciatic block had a preventive analgesic effect at 24 h.
conclusionsLong-term effects after neonatal injury highlight the need for preventive strategies. Despite effective analgesia at the time of neonatal incision, morphine as a sole analgesic did not alter the somatosensory memory of early-life surgical injury.
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