ArticleNeurobiology of aging2018
Watershed microinfarct pathology and cognition in older persons.
Article in Neurobiology of aging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Long-Term Blood Pressure Variability in Cerebral Amyloid Angiopathy is Associated with Ischemic Brain Injury and Cognitive Decline.Journal of the American Heart Association · 2026Observational
- Vascular contribution to cognitive impairment and dementia (VCID): proceedings of 2025 workshop of the Jackson Laboratory.Mammalian genome : official journal of the International Mammalian Genome Society · 2026Article
- Region-specific associations between cerebral arterial elasticity and grey matter volume: Evidence for lateral prefrontal vulnerability.bioRxiv : the preprint server for biology · 2025Article
- Article
- Article
- Aging drives cerebrovascular network remodeling and functional changes in the mouse brain.Nature communications · 2024Article
- Diagnosis and treatment of Watershed strokes: a narrative review.Journal of medicine and life · 2023Review
- Aging drives cerebrovascular network remodeling and functional changes in the mouse brain.bioRxiv : the preprint server for biology · 2023Article
- Analysis of characteristics of intracranial cavernous angioma and bleeding factors in middle-aged and elderly patients.Frontiers in neurology · 2023Article
- Association of Stroke and Cerebrovascular Pathologies With Scam Susceptibility in Older Adults.JAMA neurology · 2023Article
- Association of small vessel disease with tau pathology.Acta neuropathologica · 2022Article
- Article
- Vascular pathology and pathogenesis of cognitive impairment and dementia in older adults.Cerebral circulation - cognition and behavior · 2022Article
- Cerebrovascular disease lesions are additive and tied to vascular risk factors and cognitive impairment.Free neuropathology · 2022Article
- Reducing Your Risk of Alzheimer's Dementia: Building a Better Brain as We Age.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2021Article
- Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change and microvascular pathologies in community-dwelling older persons.Brain pathology (Zurich, Switzerland) · 2021Article
- Article
- Obesity and Brain Vulnerability in Normal and Abnormal Aging: A Multimodal MRI Study.Journal of Alzheimer's disease reports · 2021Article
- Alzheimer's Disease Neuropathological Comorbidities are Common in the Younger-Old.Journal of Alzheimer's disease : JAD · 2021Article
- Cortical microinfarcts in memory clinic patients are associated with reduced cerebral perfusion.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Brain microinfarcts are common in aging and are associated with cognitive impairment. Anterior and posterior watershed border zones lie at the territories of the anterior, middle, and posterior cerebral arteries, and are more vulnerable to hypoperfusion than brain regions outside the watershed areas. However, little is known about microinfarcts in these regions and how they relate to cognition in aging. Participants from the Rush Memory and Aging Project, a community-based clinical-pathologic study of aging, underwent detailed annual cognitive evaluations. We examined 356 consecutive autopsy cases (mean age-at-death, 91 years [SD = 6.16]; 28% men) for microinfarcts from 3 watershed brain regions (2 anterior and 1 posterior) and 8 brain regions outside the watershed regions. Linear regression models were used to examine the association of cortical watershed microinfarcts with cognition, including global cognition and 5 cognitive domains. Microinfarcts in any region were present in 133 (37%) participants, of which 50 had microinfarcts in watershed regions. Persons with multiple microinfarcts in cortical watershed regions had lower global cognition (estimate = -0.56, standard error (SE) = 0.26, p = 0.03) and lower cognitive function in the specific domains of working memory (estimate = -0.58, SE = 0.27, p = 0.03) and visuospatial abilities (estimate = -0.57, SE = 0.27, p = 0.03), even after controlling for microinfarcts in other brain regions, demographics, and age-related pathologies. Neither the presence nor multiplicity of microinfarcts in brain regions outside the cortical watershed regions were related to global cognition or any of the 5 cognitive domains. These findings suggest that multiple microinfarcts in watershed regions contribute to age-related cognitive impairment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.