Evidence map›Paper›PMID 29935220›Full record

ArticleThe Journal of allergy and clinical immunology2019

T cell-intrinsic prostaglandin E

Jinju Lee, Tomohiro Aoki, Dean Thumkeo, Ratklao Siriwach, Chengcan Yao, Shuh Narumiya

Open access · hybridAbstract read
In one paragraph

Article in The Journal of allergy and clinical immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 118 citations in OpenAlex.

  1. Review
  2. Article
  3. Dissecting PGENature communications · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Single-cell transcriptomics reveal circulating skin-homing CLAClinical and translational medicine · 2025
    Article
  8. Article
  9. A CD4Immunity · 2025
    Article
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  11. Article
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  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Jinju LeeCore Research for Evolutional Science and Technology (CREST), Medical Innovation Center, Kyoto, Japan; Kyoto University, Graduate School of Biostudies, Kyoto, Japan.
Tomohiro AokiCore Research for Evolutional Science and Technology (CREST), Medical Innovation Center, Kyoto, Japan; Center for Innovation in Immunoregulation Technology and Therapeutics, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Dean ThumkeoCore Research for Evolutional Science and Technology (CREST), Medical Innovation Center, Kyoto, Japan; Center for Innovation in Immunoregulation Technology and Therapeutics, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Ratklao SiriwachCenter for Innovation in Immunoregulation Technology and Therapeutics, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Chengcan YaoMedical Research Council (MRC) Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom. Electronic address: Chengcan.Yao@ed.ac.uk.
Shuh NarumiyaCore Research for Evolutional Science and Technology (CREST), Medical Innovation Center, Kyoto, Japan; Center for Innovation in Immunoregulation Technology and Therapeutics, Kyoto University Graduate School of Medicine, Kyoto, Japan. Electronic address: snaru@mfour.med.kyoto-u.ac.jp.
Kyoto University · JPCentre for Inflammation Research · GB

Funding

Cancer Research UK 25246Cancer Research UK A25246Medical Research Council MR/R008167/1Wellcome Trust
6 · The paper itself

Abstract

backgroundIL-23 is the key cytokine for generation of pathogenic IL-17-producing helper T (T

objectivesWe sought to examine the involvement, molecular mechanisms, and clinical implications of prostaglandin (PG) E

methodsThe role of PGE

resultsIL-23 induces Ptgs2, encoding COX2 in T

conclusionsT cell-intrinsic EP2/EP4 signaling is critical in IL-23-driven generation of pathogenic T

Indexed as

AnimalsCells, CulturedCyclic AMPDinoprostoneDisease Models, AnimalGene Expression ProfilingHumansImiquimodInflammationInterleukin-23MiceMice, Inbred C57BLMice, KnockoutPsoriasisReceptors, Prostaglandin E, EP2 SubtypeReceptors, Prostaglandin E, EP4 SubtypeCyclic AMPDinoprostoneImiquimodInterleukin-23Ptger2 protein, mousePtger4 protein, mouseReceptors, Prostaglandin E, EP2 SubtypeReceptors, Prostaglandin E, EP4 SubtypecAMP-responsive element binding protein 1IL-23 receptornuclear factor κ light chain enhancer of activated B cellspathogenic T(H)17 cellsprostaglandin E(2)prostaglandin E receptor EP2prostaglandin E receptor EP4Psoriasissignal transducer and activator of transcription 3

Identifiers

PMID29935220
PMCPMC6354914
OpenAlexW2808983332

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.