ArticleMedical physics2018
Interstitial assessment of aggressive prostate cancer by physio-chemical photoacoustics: An ex vivo study with intact human prostates.
Article in Medical physics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 25 citations in OpenAlex.
- Supervised contrastive loss helps uncover more robust features for photoacoustic prostate cancer identification.Frontiers in oncology · 2025Article
- Theoretical and experimental study of attenuation in cancellous bone.Journal of biomedical optics · 2024Article
- Photoacoustic clinical applications: Musculoskeletal and abdominal imaging.Zeitschrift fur medizinische Physik · 2023Review
- Fabrication of a translational photoacoustic needle sensing probe for interstitial photoacoustic spectral analysis.Photoacoustics · 2023Article
- Identification of different types of tumors based on photoacoustic spectral analysis: preclinical feasibility studies on skin tumors.Journal of biomedical optics · 2023Article
- Assessment of prostate cancer progression using a translational needle photoacoustic sensing probe: Preliminary study with intact human prostatesPhotoacoustics · 2022Article
- Myocardial infarct border demarcation by dual-wavelength photoacoustic spectral analysis.Photoacoustics · 2022Article
- Quick identification of prostate cancer by wavelet transform-based photoacoustic power spectrum analysis.Photoacoustics · 2022Article
- Progress of photoacoustic imaging combined with targeted photoacoustic contrast agents in tumor molecular imaging.Frontiers in chemistry · 2022Review
- Implementation of Machine Learning Mechanism for Recognising Prostate Cancer through Photoacoustic Signal.Contrast media & molecular imaging · 2022Article
- Prostate cancer identification via photoacoustic spectroscopy and machine learning.Photoacoustics · 2021Article
- Characterizing the aggressiveness of prostate cancer using an all-optical needle photoacoustic sensing probe: feasibility study.Biomedical optics express · 2021Article
- Histopathological Ratios to Predict Gleason Score Agreement between Biopsy and Radical Prostatectomy.Diagnostics (Basel, Switzerland) · 2020Article
- Photoacoustic spectral analysis at ultraviolet wavelengths for characterizing the Gleason grades of prostate cancer.Optics letters · 2020Article
- Optical-Resolution Photoacoustic Microscopy Using Transparent Ultrasound Transducer.Sensors (Basel, Switzerland) · 2019Article
- Photoacoustic tomography for imaging the prostate: a transurethral illumination probe design and application.Biomedical optics express · 2019Article
- Cylindrical illumination with angular coupling for whole-prostate photoacoustic tomography.Biomedical optics express · 2019Article
- Photoacoustic imaging of clofazimine hydrochloride nanoparticle accumulation in cancerous vs normal prostates.PloS one · 2019Article
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Authors and funding
14 authors at 5 institutions in 3 countries.
Funding
Abstract
purposeTransrectal ultrasound (TRUS)-guided biopsy is the standard procedure for evaluating the presence and aggressiveness of prostate cancer. TRUS biopsy involves tissue removal, and suffers from low core yield as well as high false negative rate. A less invasive and more accurate diagnostic procedure for prostate cancer is therefore highly desired. Combining the optical sensitivity and ultrasonic resolution to resolve the spatial distribution of the major molecular components in tissue, photoacoustic (PA) technology could be an alternative approach for the diagnosis of prostate cancer. The purpose of this study was to examine the feasibility of identifying aggressive prostate cancer using interstitial PA measurements.
methodsSeventeen patients with prebiopsy magnetic resonance imaging (MRI), TRUS biopsies, and planned prostatectomies were enrolled in this study. The interstitial PA measurements were achieved using our recently developed needle PA probe, which was inserted into the ex vivo prostates in the fashion of a biopsy needle. A total of 70 interstitial PA measurements were acquired. The PA measurements were quantified by a previously established PA physio-chemical analysis (PAPCA) method. The histology has confirmed the nonaggressive and aggressive cancerous conditions at the insertion locations. The diagnostic accuracy was also compared to that provided by the prebiopsy MRI.
resultsThe quantitative study shows significant differences between the individual parameters of the nonaggressive and the aggressive cancerous regions (P < 0.005). Multivariate analysis of the quantitative features achieved a diagnostic accuracy of 78.6% for differentiating nonaggressive and aggressive prostate cancer tissues.
conclusionsThe proposed procedure has shown promises in the diagnosis of aggressive prostate cancer.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.