Evidence map›Paper›PMID 29935001›Full record

ArticleJournal of applied clinical medical physics2018

Single-institution report of setup margins of voluntary deep-inspiration breath-hold (DIBH) whole breast radiotherapy implemented with real-time surface imaging.

Annie Xiao, Jennie Crosby, Martha Malin, Hyejoo Kang, Maxine Washington, Yasmin Hasan, Steven J Chmura, Hania A Al-Hallaq

Abstract read
In one paragraph

Article in Journal of applied clinical medical physics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Trial
  2. Video-based postural alignment improves accuracy of breath hold treatment delivery in breast cancer patients.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Annie XiaoThe University of Chicago Pritzker School of Medicine, Chicago, IL, USA.
Jennie CrosbyDepartment of Radiation and Cellular Oncology, The University of Chicago, Chicago, IL, USA.
Martha MalinDepartment of Radiation and Cellular Oncology, The University of Chicago, Chicago, IL, USA.
Hyejoo KangDepartment of Radiation Oncology, Loyola Medicine, Maywood, IL, USA.
Maxine WashingtonDepartment of Radiation and Cellular Oncology, The University of Chicago, Chicago, IL, USA.
Yasmin HasanDepartment of Radiation and Cellular Oncology, The University of Chicago, Chicago, IL, USA.
Steven J ChmuraDepartment of Radiation and Cellular Oncology, The University of Chicago, Chicago, IL, USA.
Hania A Al-HallaqDepartment of Radiation and Cellular Oncology, The University of Chicago, Chicago, IL, USA.

Funding

VIRAL ONCOLOGY CORE FACILITYP30CA014599 · NCI · UNIVERSITY OF CHICAGO · PI THOMAS F GAJEWSKI · 1985 to 2026
$122.1M
RESEARCH TRAINING IN MEDICAL PHYSICST32EB002103 · NIBIB · UNIVERSITY OF CHICAGO · PI ARMATO, SAMUEL G. · 2003 to 2019
$4.7M
Short Term Aging-Related Research ProgramT35AG029795 · NIA · UNIVERSITY OF CHICAGO · PI Vineet Arora, DAVID O MELTZER · 2008 to 2026
$1.4M
NCI NIH HHS P30 CA014599NIA NIH HHS T35 AG029795NIBIB NIH HHS T32 EB002103
6 · The paper itself

Abstract

purposeWe calculated setup margins for whole breast radiotherapy during voluntary deep-inspiration breath-hold (vDIBH) using real-time surface imaging (SI). METHODS AND MATERIALS: Patients (n = 58) with a 27-to-31 split between right- and left-sided cancers were analyzed. Treatment beams were gated using AlignRT by registering the whole breast region-of-interest to the surface generated from the simulation CT scan. AlignRT recorded (three-dimensional) 3D displacements and the beam-on-state every 0.3 s. Means and standard deviations of the displacements during vDIBH for each fraction were used to calculate setup margins. Intra-DIBH stability and the intrafraction reproducibility were estimated from the medians of the 5th to 95th percentile range of the translations in each breath-hold and fraction, respectively.

resultsA total of 7269 breath-holds were detected over 1305 fractions in which a median dose of 200 cGy was delivered. Each fraction was monitored for 5.95 ± 2.44 min. Calculated setup margins were 4.8 mm (A/P), 4.9 mm (S/I), and 6.4 mm (L/R). The intra-DIBH stability and the intrafraction reproducibility were ≤0.7 mm and ≤2.2 mm, respectively. The isotropic margin according to SI (9.2 mm) was comparable to other institutions' calculations that relied on x-ray imaging and/or spirometry for patients with left-sided cancer (9.8-11.0 mm). Likewise, intra-DIBH variability and intrafraction reproducibility of breast surface measured with SI agreed with spirometry-based positioning to within 1.2 and 0.36 mm, respectively.

conclusionsWe demonstrated that intra-DIBH variability, intrafraction reproducibility, and setup margins are similar to those reported by peer studies who utilized spirometry-based positioning.

Indexed as

Breath HoldingBreast NeoplasmsHeartHumansRadiotherapy Planning, Computer-AssistedReproducibility of ResultsRespirationRetrospective StudiesSpirometryTomography, X-Ray Computedbreast cancerdeep-inspiration breath-holdsetup errorssurface imaging

Identifiers

PMID29935001
PMCPMC6036385

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.