ArticleCerebellum (London, England)2019
The Role of the Cerebellum in Skin-Picking Disorder.
Article in Cerebellum (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Neurofeedback interventions for obsessive-compulsive and related disorders: Current evidence and future directions.Journal of psychiatric research · 2026Review
- Morphometric brain MRI findings in hair-pulling and skin-picking disorders in youth.Psychiatry research. Neuroimaging · 2025Article
- Comparing the 'When' and the 'Where' of Electrocortical Activity in Patients with Tourette Syndrome, Body-Focused Repetitive Behaviors, and Obsessive Compulsive Disorder.Journal of clinical medicine · 2024Article
- Atypical cerebellar activity and connectivity during affective touch in adults with skin-picking disorder.Brain imaging and behavior · 2024Article
- Neurobiology of subtypes of trichotillomania and skin picking disorder.CNS spectrums · 2023Article
- Negative Affectivity Moderates the Relationship between Attentional Control and Focused Skin Picking.International journal of environmental research and public health · 2022Article
- Reward processing in trichotillomania and skin picking disorder.Brain imaging and behavior · 2022Article
- Psychiatric Diagnoses and Medications in Wolfram Syndrome.Scandinavian journal of child and adolescent psychiatry and psychology · 2022Article
- Trichotillomania and Skin-Picking Disorder: An Update.Focus (American Psychiatric Publishing) · 2021Article
- Dermatillomania: Strategies for Developing Protective Biomaterials/Cloth.Pharmaceutics · 2021Review
- Article
- Resting-State Functional Connectivity of Supplementary Motor Area Associated with Skin-Picking Symptom Severity.Journal of obsessive-compulsive and related disorders · 2020Article
- Purkinje cell-specific Grip1/2 knockout mice show increased repetitive self-grooming and enhanced mGluR5 signaling in cerebellum.Neurobiology of disease · 2019Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous research indicated that the cerebellum is involved in psychopathologies with body-focused repetitive behaviors. The present study investigated whether patients with a diagnosis of skin-picking disorder (SPD) also show altered cerebellar structure and function. Structural as well as functional MRI data from 30 SPD patients and 31 controls were analyzed. The fMRI approach compared cerebellar activity and connectivity between the two groups during scratching and caressing of a small skin area on the arm. Relative to controls, SPD patients were characterized by reduced gray matter volumes in the left cerebellar lobules V and VI. During picking (relative to caressing), SPD patients displayed increased activation of the left crus I, which showed enhanced coupling with the left ventrolateral prefrontal cortex (VLPFC). This study provides the first evidence that SPD patients display structural as well as functional abnormalities in specific subregions of the cerebellum related to motor (V) and affective-cognitive functions (VI, crus I). The SPD-related altered cerebellar connectivity with an area implicated in affect control (VLPFC) fits nicely to the model of pathological skin picking as a maladaptive emotion regulation strategy.
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