ReviewCurrent reviews in musculoskeletal medicine2018
Risk Factors and Treatment Options for Failure of a Two-Stage Exchange.
Review in Current reviews in musculoskeletal medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Comparative reinfection rate of one-stage versus two-stage revision in the management of periprosthetic joint infection following total hip arthroplasty: a meta-analysis.BMC musculoskeletal disorders · 2024Pooled it
- How do pre-operative intra-articular injections impact periprosthetic joint infection risk following primary total hip arthroplasty? A systematic review and meta-analysis.Archives of orthopaedic and trauma surgery · 2023Pooled it
- Old germs, novel approaches - A systematic review on pathogen distribution and therapeutic intervention strategies in periprosthetic joint infections.European journal of microbiology & immunology · 2025Review
- Modified masquelet technique coupled with vascularized fibular transplantation (transposition) in the reconstruction of ultra-long structural bone defects following osteomyelitis debridement: clinical application and preliminary study on therapeutic outcomes.BMC musculoskeletal disorders · 2025Article
- Outcomes of a cemented modular rotational-hinge design as the final implant in a two-stage replacement due to chronic knee periprosthetic joint infection.Archives of orthopaedic and trauma surgery · 2024Article
- A simplified approach for the surgical treatment of hip and knee periprosthetic joint infections.Journal of orthopaedics · 2024Review
- Characterization of periprosthetic environment microbiome in patients after total joint arthroplasty and its potential correlation with inflammation.BMC infectious diseases · 2023Article
- Repeat two-stage exchange arthroplasty for recurrent periprosthetic hip or knee infection: what are the chances for success?Archives of orthopaedic and trauma surgery · 2023Article
- Failure analysis of articulating polymethyl methacrylate spacers in two-stage revision total hip arthroplasty.Bone & joint open · 2022Article
- Long Term Results of Two-Stage Revision for Chronic Periprosthetic Hip Infection: A Multicenter Study.Journal of clinical medicine · 2022Article
- Cocktail of isobavachalcone and curcumin enhance eradication ofFrontiers in microbiology · 2022Article
- Superinfection with Difficult-to-Treat Pathogens Significantly Reduces the Outcome of Periprosthetic Joint Infections.Antibiotics (Basel, Switzerland) · 2021Article
- GMI, an Immunomodulatory Peptide fromInternational journal of molecular sciences · 2021Article
- Periprosthetic Fungal Infections in Severe Endoprosthetic Infections of the Hip and Knee Joint-A Retrospective Analysis of a Certified Arthroplasty Centre of Excellence.Journal of fungi (Basel, Switzerland) · 2021Article
- A spacer infection by Candida albicans secondary to a Staphylococcus capitis prosthetic joint infection: a case report.BMC infectious diseases · 2021Article
- Candida Periprosthetic Joint Infection: Is It Curable?Antibiotics (Basel, Switzerland) · 2021Article
- Successful Treatment of a RecalcitrantPharmaceuticals (Basel, Switzerland) · 2021Article
- Risk factors affect success rate of debridement, antibiotics and implant retention (DAIR) in periprosthetic joint infection.Arthroplasty (London, England) · 2020Review
- The effect of metal artefact on the design of custom 3D printed acetabular implants.3D printing in medicine · 2020Article
- [Amputations around the knee].Der Orthopade · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewAlthough a two-stage exchange revision is reported to have a high success rate, this strategy may fail as a treatment for prosthetic joint infection (PJI). When it does, resection arthroplasty, arthrodesis, amputation, and chronic antibiotic suppression may play a role. The purpose of this review is to determine which are the main risk factors for a two-stage exchange failure and to analyze the indications and results of resection arthroplasty, arthrodesis, amputation, and antibiotic chronic suppression for PJI. RECENT
findingsRecent literature demonstrates that the main risk factors for a two-stage exchange failure are as follows: hemodialysis, obesity, multiple previous procedures, diabetes mellitus, corticosteroid therapy, hypoalbuminemia, immunosuppression, rheumatological conditions, coagulation disorders, and infection due to multidrug-resistant (MDR) bacteria or fungal species. Regarding microorganisms, besides Staphylococcus aureus, Streptococcus spp., Enterobacteriaceae species such as Klebsiella pneumoniae and Enterobacter sp., Pseudomonas aeruginosa, or Acinetobacter baumannii, and fungus including Candida sp. are also considered risk factors for a two-stage exchange failure. Resection arthroplasty, arthrodesis, and amputation have a limited role. Chronic suppression is an option for high-risk patients or unfeasible reconstruction. In summary, we report the main risk factors for a two-stage exchange failure and alternative procedures when it occurs. Future research on patient-specific risk factors for a two-stage exchange may aid surgical decision-making and optimization of outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.