Evidence map›Paper›PMID 29934876›Full record

ArticleEndocrine2018

Long-term follow-up of female prolactinoma patients at child-bearing age after transsphenoidal surgery.

Na Yi, Lijin Ji, Qi Zhang, Shuo Zhang, Xiaoxia Liu, Xuefei Shou, Bin Lu

Abstract read
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In one paragraph

Article in Endocrine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Na YiDepartment of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China.
Lijin JiDepartment of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China.
Qi ZhangDepartment of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China.
Shuo ZhangDepartment of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China.
Xiaoxia LiuDepartment of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China.
Xuefei ShouDepartment of Neurosurgery, Huashan Hospital Fudan University, No. 12 Wulumuqi Middle Road, Jing'an District, Shanghai, 200040, China. doctor_xuefeishou@126.com.
Bin LuDepartment of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China. doctor_lubinfudan@126.com.ORCID http://orcid.org/0000-0002-3744-5041
Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextProlactinoma is the most common subtype of functional pituitary adenoma. Effective therapy is required for women of child-bearing age to achieve remission at serum prolactin level and regain reproductive function. PURPOSE: To evaluate long-term outcomes, including menstrual recovery, after transsphenoidal surgery on female prolactinoma patients by experienced neurosurgeons.

designObservational study. PATIENTS: Consecutive female prolactinoma patients aged from 16 to 45 years were included. Histological analysis after surgery revealed adenoma with positive staining for prolactin. Plurihormonal cell adenomas were excluded. MAIN MEASUREMENTS: Clinical manifestations, surgical indications, serum prolactin level before and after surgery, surgical complications, pituitary fuctions, drug maintenance, the status of menstruation, and pregnancy.

resultsSixty-three consecutive female patients with a mean age of 29.5 ± 1.1 years were included. Based on magnetic resonance imaging findings before surgery, 31 (49.2%) patients had microadenoma, and the remaining 32 (50.8%) had macroadenoma. The median follow-up after transsphenoidal surgery was 53 (33-74) months, and long-term surgical remission was achieved in 50 (79.37%) patients with 28 (90.32%) microadenomas and 22 (68.75%) macroadenomas. No meningitis or persistent cerebrospinal fluid leaks occurred. Only one case suffered from persistent diabetes insipidus at follow-up. No severe pituitary dysfunction was observed in microprolactinoma patients. Of patients with menstrual disorders, 85% regained regular menstrual cycles after surgery. Nineteen patients in this cohort desired pregnancy and 15 of them successfully gave birth after surgery. All 17 microadenoma patients with modern surgical indications achieved normal prolactin levels and regular menstrual cycles with only one patient on drug therapy at follow-up.

conclusionLong-term follow-up showed a high remission rate in female prolactinoma patients, especially in microadenoma patients, after surgery. Transsphenoidal surgery performed by experienced neurosurgeons may offer a valuable approach to treat female microprolactinoma patients of child-bearing age with modern indications for surgery.

Indexed as

AdolescentAdultFemaleFollow-Up StudiesHumansMagnetic Resonance ImagingMiddle AgedPituitary NeoplasmsProlactinomaSphenoid SinusTreatment OutcomeYoung AdultExperienced neurosurgeonFertilityMenstrual cycleProlactinomaTranssphenoidal surgeryWomen

Identifiers

PMID29934876
OpenAlexW2808784580

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.