Evidence map›Paper›PMID 29934798›Full record

SynthesisClinical oral investigations2018

Clinical periodontal variables in patients with and without dementia-a systematic review and meta-analysis.

Alejandra Maldonado, Oliver Laugisch, Walter Bürgin, Anton Sculean, Sigrun Eick

Open access · bronzeAbstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Clinical oral investigations, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 5 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 5 syntheses or guidelines pooled it, 51 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. The Effect of Periodontitis on Dementia and Cognitive Impairment: A Meta-Analysis.International journal of environmental research and public health · 2021
    Pooled it
  5. Oral Health and Its Associated Factors Among Older Institutionalized Residents-A Systematic Review.International journal of environmental research and public health · 2019
    Pooled it
  6. Trial
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  8. Review
  9. Article
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  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Periodontitis and brain magnetic resonance imaging markers of Alzheimer's disease and cognitive aging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Alejandra MaldonadoDepartment of Periodontology, School of Dental Medicine, University of Bern, Bern, Switzerland. maldoalejandra@hotmail.com.ORCID http://orcid.org/0000-0002-9361-2625
Oliver LaugischDepartment of Periodontology, School of Dental Medicine, University of Bern, Bern, Switzerland.
Walter BürginResearch Section, School of Dental Medicine, University of Bern, Bern, Switzerland.
Anton SculeanDepartment of Periodontology, School of Dental Medicine, University of Bern, Bern, Switzerland.
Sigrun EickDepartment of Periodontology, School of Dental Medicine, University of Bern, Bern, Switzerland.
University of Bern · CH

Funding

FP7 Health 2012-306029 TRIGGER
6 · The paper itself

Abstract

backgroundConsidering the increasing number of elderly people, dementia has gained an important role in today's society. Although the contributing factors for dementia have not been fully understood, chronic periodontitis (CP) seems to have a possible link to dementia.

aimTo conduct a systematic review including meta-analysis in order to assess potential differences in clinical periodontal variables between patients with dementia and non-demented individuals.

methodsThe following focused question was evaluated: is periodontitis associated with dementia? Electronic searches in two databases, MEDLINE and EMBASE, were conducted. Meta-analysis was performed with the collected data in order to find a statistically significant difference in clinical periodontal variables between the group of dementia and the cognitive normal controls.

resultsForty-two articles remained for full text reading. Finally, seven articles met the inclusion criteria and only five studies provided data suitable for meta-analysis. Periodontal probing depth (PPD), bleeding on probing (BOP), gingival bleeding index (GBI), clinical attachment level (CAL), and plaque index (PI) were included as periodontal variables in the meta-analysis. Each variable revealed a statistically significant difference between the groups. In an attempt to reveal an overall difference between the periodontal variables in dementia patients and non-demented individuals, the chosen variables were transformed into units that resulted in a statistically significant overall difference (p < 0.00001).

conclusionThe current findings indicate that compared to systemically healthy individuals, demented patients show significantly worse clinical periodontal variables. However, further epidemiological studies including a high numbers of participants, the use of exact definitions both for dementia and chronic periodontitis and adjusted for cofounders is warranted. CLINICAL RELEVANCE: These findings appear to support the putative link between CP and dementia. Consequently, the need for periodontal screening and treatment of elderly demented people should be emphasized.

Indexed as

DementiaHumansPeriodontal DiseasesPeriodontal IndexRisk FactorsAlzheimer’s diseaseClinical periodontal variablesDementiaPeriodontitis

Identifiers

PMID29934798
OpenAlexW2809608182

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.