Evidence map›Paper›PMID 29934777›Full record

ArticleJournal of molecular medicine (Berlin, Germany)2018

Targeted resequencing of a locus for heparin-induced thrombocytopenia on chromosome 5 identified in a genome-wide association study.

Anika Witten, Juliane Bolbrinker, Andrei Barysenka, Matthias Huber, Frank Rühle, Ulrike Nowak-Göttl, Edeltraut Garbe, Reinhold Kreutz, Monika Stoll

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of molecular medicine (Berlin, Germany), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Heparin-Induced Thrombocytopenia: A Focus on Thrombosis.Arteriosclerosis, thrombosis, and vascular biology · 2021
    Review
  8. Pathogenesis of heparin-induced thrombocytopenia.Translational research : the journal of laboratory and clinical medicine · 2020
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Anika WittenDepartment of Genetic Epidemiology, Institute of Human Genetics, University Hospital Münster, Münster, Germany.
Juliane BolbrinkerCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Clinical Pharmacology and Toxicology, Berlin, Germany.
Andrei BarysenkaDepartment of Genetic Epidemiology, Institute of Human Genetics, University Hospital Münster, Münster, Germany.
Matthias HuberCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Clinical Pharmacology and Toxicology, Berlin, Germany.
Frank RühleDepartment of Genetic Epidemiology, Institute of Human Genetics, University Hospital Münster, Münster, Germany.
Ulrike Nowak-GöttlThrombosis and Hemostasis Unit, Department of Clinical Chemistry, University Hospital of Kiel and Lübeck, Kiel, Germany.
Edeltraut GarbeCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Clinical Pharmacology and Toxicology, Berlin, Germany.
Reinhold KreutzCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Clinical Pharmacology and Toxicology, Berlin, Germany.
Monika StollDepartment of Genetic Epidemiology, Institute of Human Genetics, University Hospital Münster, Münster, Germany. mstoll@uni-muenster.de.ORCID 0000-0002-2711-4281

Funding

Federal Institute for Drugs and Medical Devices in Bonn V-5238/68502-68605
6 · The paper itself

Abstract

Immune-mediated heparin-induced thrombocytopenia (HIT) is the clinically most important adverse drug reaction (ADR) in response to heparin therapy characterized by a prothrombotic state despite a decrease in platelet count. We conducted a genome-wide association study in 96 suspected HIT cases and 96 controls to explore the genetic predisposition for HIT within a case-control pharmacovigilance study followed by replication in additional 86 cases and 86 controls from the same study. One single nucleotide polymorphism (SNP, rs1433265, P = 6.5 × 10

Indexed as

Chromosomes, Human, Pair 5Genetic Predisposition to DiseaseQuantitative Trait LociAgedAllelesAnticoagulantsBiomarkersCase-Control StudiesFemaleGenome-Wide Association StudyGenotypeHeparinHigh-Throughput Nucleotide SequencingHumansMaleMiddle AgedAnticoagulantsBiomarkersHeparinADAMTS16ADRGWASHITICE1

Identifiers

PMID29934777

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.