ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2019
Surgical histopathology of limited dorsal myeloschisis with flat skin lesion.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Co-existing limited dorsal myeloschisis, spinal dermal sinus tract, and dermoid cyst in a 3-month-old female infant: Illustrative case.Radiology case reports · 2026Article
- Cervical wart-like cutaneous appendage with a contiguous stalk of limited dorsal myeloschisis treated with untethering after long-term follow-up.Surgical neurology international · 2025Article
- Saccular Limited Dorsal Myeloschisis with a Short Stalk at the Base of the Sac Causing Spinal Cord Deviation out of the Spinal Canal.NMC case report journal · 2025Article
- Limited dorsal myeloschisis without extradural stalk continuity to coexisting congenital dermal sinus.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Article
- Ectopic dorsal root ganglion in cauda equina mimicking schwannoma in a child.Surgical neurology international · 2023Article
- Focal Spinal Nondisjunctional Disorders: Including a Discussion on the Embryogenesis of Cranial Focal Nondisjunctional Lesions.Advances and technical standards in neurosurgery · 2023Review
- Focal Spinal Nondisjunction in Primary Neurulation : Limited Dorsal Myeloschisis and Congenital Spinal Dermal Sinus Tract.Journal of Korean Neurosurgical Society · 2021Article
- Atlantoaxial limited dorsal myeloschisis: A report of two cases and review of literature.Brain & spine · 2021Article
- Surgical histopathology of a filar anomaly as an additional tethering element associated with closed spinal dysraphism of primary neurulation failure.Surgical neurology international · 2021Article
- Spinal cord deformity with aggravation of tethering in saccular limited dorsal myeloschisis during the first 2 months of life.Surgical neurology international · 2021Article
- Saccular Limited Dorsal Myeloschisis with Spinal Cord Deviation out of the Spinal Canal to the Sac.NMC case report journal · 2021Article
- Terminal syringomyelia associated with lumbar limited dorsal myeloschisis.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020Article
- Human tail-like cutaneous appendage with a contiguous stalk of limited dorsal myeloschisis.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2019Article
- Limited dorsal myeloschisis with no extradural stalk linking to a flat skin lesion: a case report.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2018Article
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8 authors.
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Abstract
purposeLimited dorsal myeloschisis (LDM) is characterized by two invariable features: a focal closed neural tube defect and a fibroneural stalk linking the skin lesion to the underlying spinal cord. Although detailed histopathological findings of the LDM stalk were originally described by Pang et al., the precise relationship between the histopathological findings and clinical manifestations including intraoperative findings has not been fully determined.
methodsWe retrospectively analyzed the histopathological findings of the almost entire stalk and their relevance to the clinical manifestations in six Japanese LDM patients with flat skin lesions.
resultsGlial fibrillary acidic protein (GFAP)-immunopositive neuroglial tissues were observed in three of the six patients. Unlike neuroglial tissues, peripheral nerve fibers were observed in every stalk. In four patients, dermal melanocytosis, "Mongolian spot," was seen surrounding the cigarette-burn lesion. In three of these four patients, numerous melanocytes were distributed linearly along the long axis of the LDM stalk, which might represent migration of melanocytes from trunk neural crest cells during formation of the LDM stalk.
conclusionImmunopositivity for GFAP in the LDM stalk was observed in as few as 50% of our patients, despite the relatively extensive histopathological examination. We confirm that the clinical diagnosis of LDM should be made based on comprehensive histopathological examination as well as clinical manifestations. The profuse network of peripheral nerve fibers in every stalk and the high incidence of melanocyte accumulation associated with dermal melanocytosis might assist the histopathological diagnosis of LDM.
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