Evidence map›Paper›PMID 29934691›Full record

ArticleParasitology research2018

A new iron(III) complex-containing sulfadiazine inhibits the proliferation and induces cystogenesis of Toxoplasma gondii.

Juliana de A Portes, Nathália F B Azeredo, Pedro G T Siqueira, Tatiana Guinancio de Souza, Christiane Fernandes, Adolfo Horn, Dalber R S Candela, Wanderley de Souza, Renato A DaMatta, Sérgio H Seabra

Abstract read
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In one paragraph

Article in Parasitology research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Nanoformulation-Based 1,2,3-Triazole Sulfonamides for Anti-Tropical medicine and infectious disease · 2023
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Juliana de A PortesLaboratório de Tecnologia em Cultura de Células, Centro Universitário Estadual da Zona Oeste, Rio de Janeiro, RJ, 23070-200, Brazil.
Nathália F B AzeredoLaboratório de Ciências Químicas, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, RJ, 28013-602, Brazil.
Pedro G T SiqueiraLaboratório de Tecnologia em Cultura de Células, Centro Universitário Estadual da Zona Oeste, Rio de Janeiro, RJ, 23070-200, Brazil.
Tatiana Guinancio de SouzaLaboratório de Tecnologia em Cultura de Células, Centro Universitário Estadual da Zona Oeste, Rio de Janeiro, RJ, 23070-200, Brazil.
Christiane FernandesLaboratório de Ciências Químicas, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, RJ, 28013-602, Brazil.
Adolfo HornLaboratório de Ciências Químicas, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, RJ, 28013-602, Brazil.
Dalber R S CandelaInstituto de Física, Universidade Federal Fluminense, Niterói, RJ, 24210-346, Brazil.
Wanderley de SouzaLaboratório de Ultraestrutura Celular Hertha Meyer, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Instituto Nacional de Ciência e Tecnologia em Biologia Estrutural e Bioimagem and Centro Nacional de Biologia Estrutural e Bioimagem, Rio de Janeiro, RJ, 21941-900, Brazil.
Renato A DaMattaLaboratório de Biologia Celular e Tecidual, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, RJ, 28013-602, Brazil.
Sérgio H SeabraLaboratório de Tecnologia em Cultura de Células, Centro Universitário Estadual da Zona Oeste, Rio de Janeiro, RJ, 23070-200, Brazil. seabrash@gmail.com.
State University of Norte Fluminense · BRUniversidade Estadual da Zona Oeste · BRUniversidade Federal do Rio de Janeiro · BRNational Institute of Science and Technology for Structural Biology and Bioimaging · BRUniversidade Federal Fluminense · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We have previously shown that metallocomplexes can control the growth of Toxoplasma gondii, the agent that causes toxoplasmosis. In order to develop new metallodrugs to treat this disease, we investigated the influence of the coordination of sulfadiazine (SDZ), a drug used to treat toxoplasmosis, on the biological activity of the iron(III) complex [Fe(HBPClNOL)Cl

Indexed as

AnimalsCell LineCell ProliferationCell SurvivalIronMacaca mulattaMicroscopy, Electron, ScanningMicroscopy, Electron, TransmissionSulfadiazineToxoplasmaToxoplasmosisIronSulfadiazineCystFe(III) compoundsIC50In vitro studiesSulfadiazineToxoplasma gondii

Identifiers

PMID29934691
OpenAlexW2809523096

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.