ArticleScientific reports2018
Experimental evidence that thermal selection shapes mitochondrial genome evolution.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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37 citing papers in PubMed, 74 citations in OpenAlex.
- Introgression of thermal tolerance alleles drives adaptation despite risk of mitonuclear conflict.Molecular biology and evolution · 2026Article
- Optimal Organelle Inheritance Strategies Under Different Changing Environments and Mutational Pressures.Genome biology and evolution · 2026Article
- Climate-associated natural selection in the human mitochondrial genome.Molecular biology and evolution · 2026Article
- Unidirectional Mitochondrial Introgression Despite Limited Nuclear Admixture in North American Red-Backed Voles,Ecology and evolution · 2025Article
- Leveraging Whole Genomes, Mitochondrial DNA and Haploblocks to Decipher Complex Demographic Histories: An Example From a Broadly Admixed Arctic Fish.Molecular ecology · 2025Article
- Multi-sample long-read nanopore sequencing of Agabus bipustulatus (Coleoptera: Dytiscidae: Agabinae) mitogenome produces effectively reliable data for downstream analyses.Journal of insect science (Online) · 2025Article
- Assessing the role of mitonuclear interactions on mitochondrial function and organismal fitness in naturalEvolution letters · 2024Article
- Drivers of interlineage variability in mitogenomic evolutionary rates in Platyhelminthes.Heredity · 2024Article
- Evolution of a biological thermocouple by adaptation of cytochrome c oxidase in a subterrestrial metazoan, Halicephalobus mephisto.Communications biology · 2024Article
- Experimental Evolution in a Warming World: The Omics Era.Molecular biology and evolution · 2024Review
- Mutation pressure mediates a pattern of substitution rates with latitude and climate in carnivores.Ecology and evolution · 2024Article
- Article
- Conservation Mitonuclear Replacement: Facilitated mitochondrial adaptation for a changing world.Evolutionary applications · 2024Article
- Review
- Review
- Mitogenome selection in the evolution of key ecological strategies in the ancient hexapod class Collembola.Scientific reports · 2022Article
- Article
- New Insights into Mitochondrial-Nuclear Interactions Revealed through Analysis of Small RNAs.Genome biology and evolution · 2022Article
- The role of mitonuclear incompatibilities in allopatric speciation.Cellular and molecular life sciences : CMLS · 2022Review
- Unparalleled mitochondrial heteroplasmy andCurrent research in insect science · 2022Article
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mitochondria are essential organelles, found within eukaryotic cells, which contain their own DNA. Mitochondrial DNA (mtDNA) has traditionally been used in population genetic and biogeographic studies as a maternally-inherited and evolutionary-neutral genetic marker. However, it is now clear that polymorphisms within the mtDNA sequence are routinely non-neutral, and furthermore several studies have suggested that such mtDNA polymorphisms are also sensitive to thermal selection. These observations led to the formulation of the "mitochondrial climatic adaptation" hypothesis, for which all published evidence to date is correlational. Here, we use laboratory-based experimental evolution in the fruit fly, Drosophila melanogaster, to test whether thermal selection can shift population frequencies of two mtDNA haplogroups whose natural frequencies exhibit clinal associations with latitude along the Australian east-coast. We present experimental evidence that the thermal regime in which the laboratory populations were maintained drove changes in haplogroup frequencies across generations. Our results strengthen the emerging view that intra-specific mtDNA variants are sensitive to selection, and suggest spatial distributions of mtDNA variants in natural populations of metazoans might reflect adaptation to climatic environments rather than within-population coalescence and diffusion of selectively-neutral haplotypes across populations.
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