ArticleNature communications2018
Analysis of sensitive information leakage in functional genomics signal profiles through genomic deletions.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Proxy panels enable privacy-aware outsourcing of genotype imputation.Genome research · 2025Article
- Article
- FedGMMAT: Federated generalized linear mixed model association tests.PLoS computational biology · 2024Article
- Assessing Privacy Vulnerabilities in Genetic Data Sets: Scoping Review.JMIR bioinformatics and biotechnology · 2024Article
- Assessing transcriptomic reidentification risks using discriminative sequence models.Genome research · 2023Article
- Privacy-aware estimation of relatedness in admixed populations.Briefings in bioinformatics · 2022Article
- SVAT: Secure outsourcing of variant annotation and genotype aggregation.BMC bioinformatics · 2022Article
- Sociotechnical safeguards for genomic data privacy.Nature reviews. Genetics · 2022Review
- Privacy-Preserving Artificial Intelligence Techniques in Biomedicine.Methods of information in medicine · 2022Article
- Functional genomics data: privacy risk assessment and technological mitigation.Nature reviews. Genetics · 2022Review
- "Big Data" Approaches for Prevention of the Metabolic Syndrome.Frontiers in genetics · 2022Review
- Recovering genotypes and phenotypes using allele-specific genes.Genome biology · 2021Article
- AI applications in functional genomics.Computational and structural biotechnology journal · 2021Review
- Cardioinformatics: the nexus of bioinformatics and precision cardiology.Briefings in bioinformatics · 2020Article
- Responsible, practical genomic data sharing that accelerates research.Nature reviews. Genetics · 2020Review
- Big Data Approaches in Heart Failure Research.Current heart failure reports · 2020Review
- Using blockchain to log genome dataset access: efficient storage and query.BMC medical genomics · 2020Article
- Navigating ethical quandaries with the privacy dilemma of biomedical datasets.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2020Article
- Emerging technologies towards enhancing privacy in genomic data sharing.Genome biology · 2019Article
- When Biology Gets Personal: Hidden Challenges of Privacy and Ethics in Biological Big Data.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2019Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Functional genomics experiments, such as RNA-seq, provide non-individual specific information about gene expression under different conditions such as disease and normal. There is great desire to share these data. However, privacy concerns often preclude sharing of the raw reads. To enable safe sharing, aggregated summaries such as read-depth signal profiles and levels of gene expression are used. Projects such as GTEx and ENCODE share these because they ostensibly do not leak much identifying information. Here, we attempt to quantify the validity of this statement, measuring the leakage of genomic deletions from signal profiles. We present information theoretic measures for the degree to which one can genotype these deletions. We then develop practical genotyping approaches and demonstrate how to use these to identify an individual within a large cohort in the context of linking attacks. Finally, we present an anonymization method removing much of the leakage from signal profiles.
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