ArticleScientific reports2018
Impact of specific functional groups in flavonoids on the modulation of platelet activation.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 38 citations in OpenAlex.
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- Structure-Activity Relationship Analysis of Rhosin, a RhoA GTPase Inhibitor, Reveals a New Class of Antiplatelet Agents.International journal of molecular sciences · 2023Article
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- An ethnopharmacological review on the therapeutical properties of flavonoids and their mechanisms of actions: A comprehensive review based on up to date knowledge.Toxicology reports · 2022Review
- Astragalin Inhibits Cigarette Smoke-Induced Pulmonary Thrombosis and Alveolar Inflammation and Disrupts PAR Activation and Oxidative Stress-Responsive MAPK-Signaling.International journal of molecular sciences · 2021Article
- Phenolic Bioactives as Antiplatelet Aggregation Factors: The Pivotal Ingredients in Maintaining Cardiovascular Health.Oxidative medicine and cellular longevity · 2021Review
- Anti-platelet role of Korean ginseng and ginsenosides in cardiovascular diseases.Journal of ginseng research · 2020Review
- Effect of ultrapure lipopolysaccharides derived from diverse bacterial species on the modulation of platelet activation.Scientific reports · 2019Article
- Synthetic Flavonoids as Novel Modulators of Platelet Function and Thrombosis.International journal of molecular sciences · 2019Review
- Beneficial Effects of Citrus Flavonoids on Cardiovascular and Metabolic Health.Oxidative medicine and cellular longevity · 2019Review
- The endogenous antimicrobial cathelicidin LL37 induces platelet activation and augments thrombus formation.Blood advances · 2018Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Flavonoids exert innumerable beneficial effects on cardiovascular health including the reduction of platelet activation, and thereby, thrombosis. Hence, flavonoids are deemed to be a molecular template for the design of novel therapeutic agents for various diseases including thrombotic conditions. However, the structure-activity relationships of flavonoids with platelets is not fully understood. Therefore, this study aims to advance the current knowledge on structure-activity relationships of flavonoids through a systematic analysis of structurally-related flavones. Here, we investigated a panel of 16 synthetic flavones containing hydroxy or methoxy groups at C-7,8 positions on the A-ring, with a phenyl group or its bioisosteres as the B-ring, along with their thio analogues possessing a sulfur molecule at the 4
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Registered trials
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