Evidence map›Paper›PMID 29934585›Full record

ArticleNature communications2018

Stem cell factor is selectively secreted by arterial endothelial cells in bone marrow.

Chunliang Xu, Xin Gao, Qiaozhi Wei, Fumio Nakahara, Samuel E Zimmerman, Jessica Mar, Paul S Frenette

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 131 papers.

0numbers the graph read from it
0cells of the map it votes in
131citing papers in PubMed
10.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

131 citing papers in PubMed, 207 citations in OpenAlex.

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  9. Mechanometabolism instructs hematopoietic stem cell specification.The Journal of experimental medicine · 2026
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71 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Chunliang XuThe Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, New York, NY, 10461, USA.
Xin GaoThe Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, New York, NY, 10461, USA.
Qiaozhi WeiThe Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, New York, NY, 10461, USA.
Fumio NakaharaThe Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, New York, NY, 10461, USA.ORCID http://orcid.org/0000-0003-1515-8284
Samuel E ZimmermanDepartment of Systems and Computational Biology, Albert Einstein College of Medicine, New York, NY, 10461, USA.
Jessica MarDepartment of Systems and Computational Biology, Albert Einstein College of Medicine, New York, NY, 10461, USA.
Paul S FrenetteThe Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, New York, NY, 10461, USA. paul.frenette@einstein.yu.edu.ORCID http://orcid.org/0000-0003-0862-9922
Albert Einstein College of Medicine · US

Funding

In Vivo Sickle Cell Vasoocclusion: Adhesion MechanismsR01HL069438 · NHLBI · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI KELLY, LIBUSHA · 2001 to 2024
$9.5M
Regulation and function of hematopoietic stem cell nichesR01DK056638 · NIDDK · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI GRITSMAN, KIRA · 2000 to 2023
$8.7M
Mechanisms regulating the aging of HSC nichesR01DK112976 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI FRENETTE, PAUL S · 2018 to 2021
$1.5M
Evaluating neural circuitry of the bone marrowU01DK116312 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI FRENETTE, PAUL S · 2017 to 2019
$1.3M
NHLBI NIH HHS R01 HL069438NIDDK NIH HHS R01 DK056638NIDDK NIH HHS R01 DK112976NIDDK NIH HHS U01 DK116312U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL069438U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) DK056638U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) DK112976U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) DK116312
6 · The paper itself

Abstract

Endothelial cells (ECs) contribute to haematopoietic stem cell (HSC) maintenance in bone marrow, but the differential contributions of EC subtypes remain unknown, owing to the lack of methods to separate with high purity arterial endothelial cells (AECs) from sinusoidal endothelial cells (SECs). Here we show that the combination of podoplanin (PDPN) and Sca-1 expression distinguishes AECs (CD45

Indexed as

AnimalsAntigens, LyArteriesBone MarrowBone Marrow CellsBone Marrow TransplantationCapillariesCell DifferentiationCells, CulturedEndothelial CellsFemaleHematopoietic Stem CellsMaleMembrane GlycoproteinsMembrane ProteinsMiceAntigens, LyKITL2 protein, mouseLy6a protein, mouseMembrane GlycoproteinsMembrane ProteinsPdpn protein, mousePodoplaninStem Cell Factor

Identifiers

PMID29934585
PMCPMC6015052
OpenAlexW2809282001

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.