ArticleScientific reports2018
Prognostic Significance of Infarct Size and Location: The Case of Insular Stroke.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 6 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
51 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Pooled it
- A systematic review of alterations in sensorimotor networks following stroke: implications for integration and functional outcomes across recovery stages.Frontiers in neurology · 2025Pooled it
- Efficacy of bumetanide in animal models of ischemic stroke: a systematic review and meta-analysis.Aging · 2024Pooled it
- The relationship between nutritional status at the time of stroke on adverse outcomes: a systematic review and meta-analysis of prospective cohort studies.Nutrition reviews · 2022Pooled it
- Clinical presentation of strokes confined to the insula: a systematic review of literature.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Pooled it
- The effect of angiopoietin-1 upregulation on the outcome of acute ischaemic stroke in rodent models: A meta-analysis.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Pooled it
- Safety and Efficacy of Intravenous Thrombolysis by Infarct Type in Patients with No Visible Occlusion: A Secondary Analysis of the AcT Trial.Journal of the American Heart Association · 2025Trial
- Functional Outcome Prediction in Acute Ischemic Stroke Using a Fused Imaging and Clinical Deep Learning Model.Stroke · 2023Trial
- Early effect of thrombolysis on structural brain network organisation after anterior-circulation stroke in the randomized WAKE-UP trial.Human brain mapping · 2022Trial
- Insular involvement and atrial fibrillation first detected after ischemic stroke: a systematic review and meta-analysis.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026Review
- Factors associated with symptom relief and lesion formation in acute ischemic stroke and transient ischemic attack.BMC neurology · 2026Article
- Remote Ischemic Conditioning on Infarct Growth in Patients With Acute Ischemic Stroke: Subgroup Analysis From the RESIST Trial.Stroke (Hoboken, N.J.) · 2026Article
- Optimizing the Approach to Calculating CST Lesion Load in Ischemic Stroke Patients for Understanding Motor Outcomes.Neurorehabilitation and neural repair · 2026Article
- Analysis of the baseline multiphase computed tomographic angiography findings to predict clinical outcomes in patients with middle cerebral artery M1 occlusion treated with mechanical thrombectomy.Diagnostic and interventional radiology (Ankara, Turkey) · 2026Article
- Neuroprotective response against the onset of ischemic stroke by upregulation of histone H3Y99 sulfation.Cell reports. Medicine · 2026Article
- Therapeutic support and functional disability after ischemic stroke: a cohort study.Revista brasileira de enfermagem · 2026Article
- Neurorehabilitation Combining Acupuncture and Conventional Rehabilitation in the Acute Ischemic Stroke: Evidence From Multimodal MRI.Neural plasticity · 2026Article
- Review
- Predictors of poor outcomes in patients with intracerebral hemorrhage.Frontiers in neurology · 2025Article
- APIS: a paired CT-MRI dataset for ischemic stroke segmentation - methods and challenges.Scientific reports · 2024Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The prognostic relevance of strokes in different locations is debated. For example, insular strokes have been associated with increased mortality, but this association could reflect their greater severity. In two independent cohorts of patients with supratentorial ischemic stroke (n = 90 and 105), we studied the prognostic consequences of lesion size and location using voxel-based lesion-symptom mapping before and after volume control, which better accounts for total lesion volume. Strokes affecting the insula were larger than non-insular strokes (28 vs 2cc and 25 vs 3cc, p < 0.001 in both cohorts). A number of supratentorial areas (mainly in the left hemisphere), including the insula, were associated with poor functional outcome in both cohorts before (4014 voxels) and after volume control (1378 voxels), while the associations with death were greatly reduced after volume control (from 8716 to 325 voxels). Exploratory analyses suggested that the method of lesion volume quantification, the National Institutes of Health Stroke Scale hemispheric bias and patient selection can result in false associations between specific brain lesions and outcomes. In conclusion, death in the first months after stroke is mainly explained by large infarct volumes, whereas lesions of specific supratentorial structures, mostly in the left hemisphere, also contribute to poor functional outcomes.
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