ArticleScientific reports2018
Real-time ex-vivo measurement of brain metabolism using hyperpolarized [1-
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The trial behind it
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Who cites it
8 citing papers in PubMed.
- Anti-Fibrotic and Anti-Inflammatory Effects of Hesperidin in an Ex Vivo Mouse Model of Early-Onset Liver Fibrosis.International journal of molecular sciences · 2026Article
- Accumulation of 3-aminopropylphosphonate in the ex vivo brain observed by phosphorus-31 nuclear magnetic resonance.NMR in biomedicine · 2022Article
- Real-Time Non-Invasive and Direct Determination of Lactate Dehydrogenase Activity in Cerebral Organoids-A New Method to Characterize the Metabolism of Brain Organoids?Pharmaceuticals (Basel, Switzerland) · 2021Article
- Curbing action potential generation or ATP-synthase leads to a decrease in in-cell pyruvate dehydrogenase activity in rat cerebrum slices.Scientific reports · 2021Article
- LDH and PDH Activities in the Ischemic Brain and the Effect of Reperfusion-An Ex Vivo MR Study in Rat Brain Slices Using Hyperpolarized [1-Metabolites · 2021Article
- Imaging Brain Metabolism Using HyperpolarizedTrends in neurosciences · 2020Review
- In-cell determination of Lactate Dehydrogenase Activity in a Luminal Breast Cancer Model ⁻Sensors (Basel, Switzerland) · 2019Article
- Assessing Cerebral Metabolism in the Immature Rodent: From Extracts to Real-Time Assessments.Developmental neuroscience · 2018Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
The ability to directly monitor in vivo brain metabolism in real time in a matter of seconds using the dissolution dynamic nuclear polarization technology holds promise to aid the understanding of brain physiology in health and disease. However, translating the hyperpolarized signal observed in the brain to cerebral metabolic rates is not straightforward, as the observed in vivo signals reflect also the influx of metabolites produced in the body, the cerebral blood volume, and the rate of transport across the blood brain barrier. We introduce a method to study rapid metabolism of hyperpolarized substrates in the viable rat brain slices preparation, an established ex vivo model of the brain. By retrospective evaluation of tissue motion and settling from analysis of the signal of the hyperpolarized [1-
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