Evidence map›Paper›PMID 29934497›Full record

ArticleEmerging microbes & infections2018

Changes in intestinal microbiota in HIV-1-infected subjects following cART initiation: influence of CD4+ T cell count.

Yongjia Ji, Fengdi Zhang, Renfang Zhang, Yinzhong Shen, Li Liu, Jiangrong Wang, Junyang Yang, Qi Tang, Jingna Xun, Tangkai Qi and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Emerging microbes & infections, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yongjia JiDepartment of Infectious Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai, 201508, China.
Fengdi ZhangDepartment of Infectious Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai, 201508, China.
Renfang ZhangDepartment of Infectious Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai, 201508, China.
Yinzhong ShenDepartment of Infectious Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai, 201508, China.
Li LiuDepartment of Infectious Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai, 201508, China.
Jiangrong WangDepartment of Infectious Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai, 201508, China.
Junyang YangDepartment of Infectious Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai, 201508, China.
Qi TangDepartment of Infectious Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai, 201508, China.
Jingna XunDepartment of Infectious Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai, 201508, China.
Tangkai QiDepartment of Infectious Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai, 201508, China.
Zhenyan WangDepartment of Infectious Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai, 201508, China.
Wei SongDepartment of Infectious Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai, 201508, China.
Yang TangDepartment of Infectious Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai, 201508, China.
Jun ChenDepartment of Infectious Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai, 201508, China. qtchenjun@163.com.
Hongzhou LuDepartment of Infectious Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai, 201508, China. luhongzhou@fudan.edu.cn.

Funding

National Natural Science Foundation of China (National Science Foundation of China) 81571977
6 · The paper itself

Abstract

The roles of immunodeficiency and combined antiretroviral therapy (cART) in shaping the gut microbiota in HIV-1-infected subjects (HISs) have not been described thoroughly by time-series investigations. In this study, 36 antiretroviral-naïve HISs were enrolled to prospectively assess alterations in the fecal microbiota and plasma markers of microbial translocation and inflammation with cART. At baseline, the species α-diversity of the fecal microbiota was significantly lower in HISs with a CD4

Indexed as

CD4 Lymphocyte CountGastrointestinal MicrobiomeAdultAntiretroviral Therapy, Highly ActiveBiodiversityBiomarkersCD4-CD8 RatioComputational BiologyFemaleHIV-1HIV InfectionsHumansMaleMetagenomeMetagenomicsRNA, Ribosomal, 16SBiomarkersRNA, Ribosomal, 16S

Identifiers

PMID29934497
PMCPMC6015051

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.