SynthesisJournal of the American Heart Association2018
Infective Endocarditis After Melody Valve Implantation in the Pulmonary Position: A Systematic Review.
Synthesis in Journal of the American Heart Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 114 citations in OpenAlex.
- Incidence of Infective Endocarditis Post-TPVR with MELODY Valve in Pediatric Patients: A Systematic Review and Meta-Analysis.Current cardiology reviews · 2025Pooled it
- Infective Endocarditis After Melody Valve Implantation in the Pulmonary Position: A Systematic Review.Journal of the American Heart Association · 2018Pooled it
- Infective endocarditis in the pediatric population: A single-center retrospective study of outcomes and predictors.European journal of pediatrics · 2026Article
- Changing Patterns in Infective Endocarditis: A Contemporary Epidemiological Perspective.Pathogens (Basel, Switzerland) · 2026Review
- Medical Versus Surgical Therapy of Infected Percutaneous Pulmonary Valve.Pediatric cardiology · 2026Article
- Clinical outcomes of injectable and conventional pulmonary valve replacement in severe pulmonary regurgitation.Turkish journal of medical sciences · 2026Article
- Endocarditis due toRevista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2025Article
- Culture-Negative Transcatheter Pulmonary Valve Endocarditis.JACC. Case reports · 2025Article
- Serial Changes in Right Ventricular Outflow Tract Gradient and Endocarditis Risk After Transcatheter Pulmonary Valve Replacement.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2025Article
- Predictors of Valve Failure Following Surgical Atrioventricular Valve Replacement with a Melody Valve in Infants and Children.Pediatric cardiology · 2025Article
- Multimodality Imaging Approach to Infective Endocarditis: Current Opinion in Patients with Congenital Heart Disease.Journal of clinical medicine · 2025Review
- The crucial role of 18F-fluorodeoxyglucose positron emission tomography/computed tomography in diagnosing pulmonary valve endocarditis in patients after transcatheter pulmonary valve implantation: a case report.European heart journal. Case reports · 2025Article
- Advancements and Challenges in the Management of Prosthetic Valve Endocarditis: A Review.Pathogens (Basel, Switzerland) · 2024Review
- Melody transcatheter pulmonary valve replacement: a single-center case series in Southeast Asia.BMC cardiovascular disorders · 2024Article
- Risk of infective endocarditis after hybrid melody mitral valve replacement in infants: the French experience.Interdisciplinary cardiovascular and thoracic surgery · 2024Article
- Matched comparison of decellularized homografts and bovine jugular vein conduits for pulmonary valve replacement in congenital heart disease.Cell and tissue banking · 2024Article
- Optimal Surgical Management of Tetralogy of Fallot.CJC pediatric and congenital heart disease · 2023Review
- The Aging Patient With Tetralogy of Fallot: Out of the Blue and Into the Pink.CJC pediatric and congenital heart disease · 2023Article
- Access to Specialized Care Across the Lifespan in Tetralogy of Fallot.CJC pediatric and congenital heart disease · 2023Review
- Unmet Clinical Needs for Transcatheter Pulmonary Valves.Annals of biomedical engineering · 2023Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInfective endocarditis (IE) after transcatheter pulmonary valve implantation (TPVI) in dysfunctioning right ventricular outflow tract conduits has evoked growing concerns. We aimed to investigate the incidence and the natural history of IE after TPVI with the Melody valve through a systematic review of published data. METHODS AND
resultsPubMed, EMBASE, and Web of Science databases were systematically searched for articles published until March 2017, reporting on IE after TPVI with the Melody valve. Nine studies (including 851 patients and 2060 patient-years of follow-up) were included in the analysis of the incidence of IE. The cumulative incidence of IE ranged from 3.2% to 25.0%, whereas the annualized incidence rate ranged from 1.3% to 9.1% per patient-year. The median (interquartile range) time from TPVI to the onset of IE was 18.0 (9.0-30.4) months (range, 1.0-72.0 months). The most common findings were positive blood culture (93%), fever (89%), and new, significant, and/or progressive right ventricular outflow tract obstruction (79%); vegetations were detectable on echocardiography in only 34% of cases. Of 69 patients with IE after TPVI, 6 (8.7%) died and 35 (52%) underwent surgical and/or transcatheter reintervention. Death or reintervention was more common in patients with new/significant right ventricular outflow tract obstruction (69% versus 33%;
conclusionsThe incidence of IE after implantation of a Melody valve is significant, at least over the first 3 years after TPVI, and varies considerably between the studies. Although surgical/percutaneous reintervention is a common consequence, some patients can be managed medically, especially those with streptococcal infection and no right ventricular outflow tract obstruction.
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