Observational studyJournal of the American Heart Association2018
Sleep Apnea, the Risk of Developing Heart Failure, and Potential Benefits of Continuous Positive Airway Pressure (CPAP) Therapy.
Observational study in Journal of the American Heart Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 55 citations in OpenAlex.
- DAHOS Study: Efficacy of dapagliflozin in treating heart failure with reduced ejection fraction and obstructive sleep apnea syndrome - A 3-month, multicenter, randomized controlled clinical trial.European journal of clinical pharmacology · 2024Trial
- Navigating sleep apnea in Scandinavia - a journey of contrasts.International journal of qualitative studies on health and well-being · 2026Article
- Obstructive Sleep Apnea and Arrhythmia: A Narrative Review of Arrhythmogenic Mechanisms.Diagnostics (Basel, Switzerland) · 2026Review
- Obstructive sleep apnea in type 2 diabetes: prevalence and limitations of the Berlin questionnaire and Epworth sleepiness scale in identifying high-risk patients.Sleep & breathing = Schlaf & Atmung · 2025Article
- Impact of sleep apnea treatment on cardiometabolic parameters in a large national multicenter alliance registry.American journal of preventive cardiology · 2025Article
- The chronobiology of human heart failure: clinical implications and therapeutic opportunities.Heart failure reviews · 2025Review
- Obstructive sleep apnoea and risk of dementia: a Danish population-based cohort study.BMJ neurology open · 2025Article
- The Association between Obstructive Sleep Apnea and Venous Thromboembolism: A Bidirectional Two-Sample Mendelian Randomization Study.Thrombosis and haemostasis · 2024Article
- Obstructive Sleep Apnea and Medical Comorbidities in the Asian Population: Evidence From a Nationwide Healthcare System Data in South Korea.Psychiatry investigation · 2024Article
- Obstructive sleep apnea and hypertension; critical overview.Clinical hypertension · 2024Review
- Sleep Apnea and Atrial Fibrillation: Clinical Features and Screening Diagnostic Options.Journal of personalized medicine · 2024Article
- Sleep Apnea and Heart Failure-Current State-of-The-Art.International journal of molecular sciences · 2024Review
- Approach the Patient With Obstructive Sleep Apnea and Obesity.The Journal of clinical endocrinology and metabolism · 2024Article
- A Saudi Heart Association Position Statement on Obesity and Cardiovascular Disease.Journal of the Saudi Heart Association · 2024Article
- Article
- Association between Obstructive Sleep Apnea and Heart Failure in Adults-A Systematic Review.Journal of clinical medicine · 2023Review
- Outcomes in Patients with Acute Myocardial Infarction and Known Sleep Apnea: A Nationwide Analysis.Journal of clinical medicine · 2023Article
- Article
- Eating habit of adding salt to foods and incident sleep apnea: a prospective cohort study.Respiratory research · 2023Article
- Sleep Apnea and Physical Movement During Sleep, But Not Sleep Duration, Are Independently Associated With Progression of Left Ventricular Diastolic Dysfunction: Prospective Hyogo Sleep Cardio-Autonomic Atherosclerosis Cohort Study.Journal of the American Heart Association · 2022Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhether there is an association between sleep apnea (SA) and the risk of developing heart failure (HF) is unclear. Furthermore, it has never been established whether continuous positive airway pressure (CPAP) therapy can prevent development of HF. We aimed to investigate SA patients' risk of developing HF and the association of CPAP therapy. METHODS AND
resultsUsing nationwide databases, the entire Danish population was followed from 2000 until 2012. patients with SA receiving and not receiving CPAP therapy were identified and compared with the background population. The primary end point was first-time hospital contact for HF and adjusted incidence rate ratios of HF were calculated using Poisson regression models. Among 4.9 million individuals included, 40 485 developed SA during the study period (median age: 53.4 years, 78.5% men) of whom 45.2% received CPAP therapy. Crude rates of HF were increased in all patients with SA relative to the background population. In the adjusted model, the incidence rate ratios of HF were increased in the untreated SA patients of all ages, compared with the background population. Comparing the CPAP-treated patients with SA with the untreated patients with SA showed significantly lower incidence rate ratios of HF among older patients.
conclusionsIn this nationwide cohort study, SA not treated with CPAP was associated with an increased risk of HF in patients of all ages. Use of CPAP therapy was associated with a lower risk of incident HF in patients >60 years of age, suggesting a protective effect of CPAP therapy in the elderly.
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