ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018
The Neuroregenerative Capacity of Olfactory Stem Cells Is Not Limitless: Implications for Aging.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 73 citations in OpenAlex.
- Aging-related olfactory loss is associated with olfactory stem cell transcriptional alterations in humans.The Journal of clinical investigation · 2022Trial
- The association between olfactory dysfunction and cardiovascular disease and its risk factors in middle-aged and older adults.Scientific reports · 2021Trial
- Construction ofiScience · 2026Article
- Effects of acute intranasal allergen exposure on resident immune cells and sensory neurons in the mouse olfactory epithelium.bioRxiv : the preprint server for biology · 2026Article
- Olfactory immunity: defending the neural-mucosal barrier.Journal of immunology (Baltimore, Md. : 1950) · 2026Review
- Importance of Smell Loss to Patients With Chronic Rhinosinusitis With Nasal Polyps: Options for Management and Recovery.Clinical and translational allergy · 2026Review
- Mechanical constraints on cell plasticity: insights from the olfactory epithelium.Frontiers in cell and developmental biology · 2026Review
- Olfactory models as a platform for neuroscience research.Frontiers in cellular neuroscience · 2026Review
- Viral destruction of the olfactory mucosa elicits immune residence, bone metaplasia, and long-term smell loss.Mucosal immunology · 2025Article
- Review
- Quiescent horizontal basal stem cells act as a niche for olfactory neurogenesis in a mouse 3D organoid model.Cell reports methods · 2025Article
- Aging and chronic inflammation: impacts on olfactory dysfunction-a comprehensive review.Cellular and molecular life sciences : CMLS · 2025Review
- Ultrastructural and developmental anatomy of the peripheral olfactory organs ofOpen veterinary journal · 2025Article
- Role and Mechanism of Olfactory Stem Cells in the Treatment of Olfactory Disorders.Stem cells international · 2025Review
- An in vitro model of acute horizontal basal cell activation reveals gene regulatory networks underlying the nascent activation phase.Stem cell reports · 2024Article
- Article
- Olfactory Loss in Rhinosinusitis: Mechanisms of Loss and Recovery.International journal of molecular sciences · 2024Review
- Type 2 and Non-type 2 Inflammation in the Upper Airways: Cellular and Molecular Alterations in Olfactory Neuroepithelium Cell Populations.Current allergy and asthma reports · 2024Review
- Integrating the patient's voice into the research agenda for treatment of chemosensory disorders.Chemical senses · 2024Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 2 countries.
Funding
Abstract
The olfactory epithelium (OE) of vertebrates is a highly regenerative neuroepithelium that is maintained under normal conditions by a population of stem and progenitor cells, globose basal cells (GBCs), which also contribute to epithelial reconstitution after injury. However, aging of the OE often leads to neurogenic exhaustion, the disappearance of both GBCs and olfactory sensory neurons (OSNs). Aneuronal tissue may remain as olfactory, with an uninterrupted sheet of apically arrayed microvillar-capped sustentacular cell, or may undergo respiratory metaplasia. We have generated a transgenic mouse model for neurogenic exhaustion using olfactory marker protein-driven Tet-off regulation of the A subunit of
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.