ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018
Distinct Populations of Motor Thalamic Neurons Encode Action Initiation, Action Selection, and Movement Vigor.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 53 citations in OpenAlex.
- A comparison of movement-related neuronal activities in cerebellar- and basal ganglia-recipient regions of the macaque thalamus.bioRxiv : the preprint server for biology · 2026Article
- Hierarchical binding of cognition to action in the human basal ganglia-thalamic circuit.bioRxiv : the preprint server for biology · 2026Article
- Histaminergic Innervation of the Ventral Anterior Thalamic Nucleus Alleviates Motor Deficits in a 6-OHDA-Induced Rat Model of Parkinson's Disease.Neuroscience bulletin · 2025Article
- Lesion distribution and network mapping in dyskinetic cerebral palsy.Brain communications · 2025Article
- Berberine alleviates chronic pain-induced anxiety-like behaviors by inhibiting the activation of VLT-projecting cACC (Cg2) neurons.Communications biology · 2024Article
- Article
- Specific connectivity optimizes learning in thalamocortical loops.Cell reports · 2024Article
- Article
- The Interactions of Temporal and Sensory Representations in the Basal Ganglia.Advances in experimental medicine and biology · 2024Review
- Reduced thalamic excitation to motor cortical pyramidal tract neurons in parkinsonism.Science advances · 2023Article
- The thalamic clustering coefficient moderates the vigor-sleep quality relationship.Sleep and biological rhythms · 2023Article
- Thalamocortical Mechanisms Underlying Real and Imagined Acupuncture.Biomedicines · 2023Article
- Article
- Functional mapping of sensorimotor activation in the human thalamus at 9.4 Tesla.Frontiers in neuroscience · 2023Article
- Oscillatory waveform sharpness asymmetry changes in motor thalamus and motor cortex in a rat model of Parkinson's disease.Experimental neurology · 2022Article
- Article
- Thunderstruck: The ACDC model of flexible sequences and rhythms in recurrent neural circuits.PLoS computational biology · 2022Article
- A neurophysiologically interpretable deep neural network predicts complex movement components from brain activity.Scientific reports · 2022Article
- Afferent and efferent projections of the rostral anterior cingulate cortex in young and middle-aged mice.Frontiers in aging neuroscience · 2022Article
- Functional Interactions Between the Parafascicular Thalamic Nucleus and Motor Cortex Are Altered in Hemiparkinsonian Rat.Frontiers in aging neuroscience · 2022Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Motor thalamus (Mthal) comprises the ventral anterior, ventral lateral, and ventral medial thalamic nuclei in rodents. This subcortical hub receives input from the basal ganglia (BG), cerebellum, and reticular thalamus in addition to connecting reciprocally with motor cortical regions. Despite the central location of Mthal, the mechanisms by which it influences movement remain unclear. To determine its role in generating ballistic, goal-directed movement, we recorded single-unit Mthal activity as male rats performed a two-alternative forced-choice task. A large population of Mthal neurons increased their firing briefly near movement initiation and could be segregated into functional groups based on their behavioral correlates. The activity of "initiation" units was more tightly locked to instructional cues than movement onset, did not predict which direction the rat would move, and was anticorrelated with reaction time (RT). Conversely, the activity of "execution" units was more tightly locked to movement onset than instructional cues, predicted which direction the rat would move, and was anticorrelated with both RT and movement time. These results suggest that Mthal influences choice RT performance in two stages: short latency, nonspecific action initiation followed by action selection/invigoration. We discuss the implications of these results for models of motor control incorporating BG and cerebellar circuits.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.