ArticleScience immunology2018
Mitochondria maintain controlled activation state of epithelial-resident T lymphocytes.
Article in Science immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed.
- Crosstalk between the microbiota and intestinal γδ T cell compartments in health and IBD.Gut microbes · 2026Review
- Boosting T cell antioxidant capacity: A strategic approach to overcome immunosuppression in solid tumors.Redox biology · 2026Review
- Article
- Interplay of anemia in inborn errors of energy metabolism.Scientific reports · 2026Observational
- T Cell Exhaustion as a Regulated Differentiation Programme.European journal of immunology · 2026Review
- Cardiolipin preserves TNature metabolism · 2026Article
- Spatial instruction of tissue immunity.ImmunoHorizons · 2026Review
- Metabolic control of innate-like T cells.Nature reviews. Immunology · 2026Review
- Mitochondria and lysosomes in T cell immunometabolism.Trends in immunology · 2025Review
- Conserved developmental rewiring of the TCR signalosome drives tolerance in innate-like lymphocytes.bioRxiv : the preprint server for biology · 2025Article
- KLRG1 identifies regulatory T cells with mitochondrial alterations that accumulate with aging.Nature aging · 2025Article
- Mouse CD8+ T cell subsets differentially generate IL-17-expressing cells in the colon epithelium and lamina propria.Clinical and experimental immunology · 2025Article
- CRISPR screens unveil nutrient-dependent lysosomal and mitochondrial nodes impacting intestinal tissue-resident memory CD8Immunity · 2024Article
- Stress triggers gut dysbiosis via CRH-CRHR1-mitochondria pathway.NPJ biofilms and microbiomes · 2024Article
- Tissue-resident memory T cells: decoding intra-organ diversity with a gut perspective.Inflammation and regeneration · 2024Review
- Prostaglandin ENature communications · 2024Article
- Dietary environmental factors shape the immune defense against Cryptosporidium infection.Cell host & microbe · 2023Article
- Transcriptomes and metabolism define mouse and human MAIT cell populations.Science immunology · 2023Article
- CD8Nature communications · 2023Article
- Article
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
Epithelial-resident T lymphocytes, such as intraepithelial lymphocytes (IELs) located at the intestinal barrier, can offer swift protection against invading pathogens. Lymphocyte activation is strictly regulated because of its potential harmful nature and metabolic cost, and most lymphocytes are maintained in a quiescent state. However, IELs are kept in a heightened state of activation resembling effector T cells but without cytokine production or clonal proliferation. We show that this controlled activation state correlates with alterations in the IEL mitochondrial membrane, especially the cardiolipin composition. Upon inflammation, the cardiolipin composition is altered to support IEL proliferation and effector function. Furthermore, we show that cardiolipin makeup can particularly restrict swift IEL proliferation and effector functions, reducing microbial containment capability. These findings uncover an alternative mechanism to control cellular activity, special to epithelial-resident T cells, and a novel role for mitochondria, maintaining cells in a metabolically poised state while enabling rapid progression to full functionality.
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Registered trials
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