Evidence map›Paper›PMID 29934339›Full record

ArticleJournal of lipid research2018

FTO mediates cell-autonomous effects on adipogenesis and adipocyte lipid content by regulating gene expression via 6mA DNA modifications.

Jayne F Martin Carli, Charles A LeDuc, Yiying Zhang, George Stratigopoulos, Rudolph L Leibel

Open access · hybridAbstract read
In one paragraph

Article in Journal of lipid research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Fto-mediated mJournal of biomedical science · 2025
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Technologies, strategies, and cautions when deconvoluting genome-wide association signals: FTO in focus.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2023
    Review
  16. Food technology and biotechnology · 2023
    Review
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jayne F Martin CarliColumbia University Medical Center, New York, NY 10032 jayne.martincarli@ucdenver.edu.ORCID 0000-0002-2568-2912
Charles A LeDucColumbia University Medical Center, New York, NY 10032.ORCID 0000-0002-2073-5050
Yiying ZhangColumbia University Medical Center, New York, NY 10032.ORCID 0000-0002-0366-0165
George StratigopoulosColumbia University Medical Center, New York, NY 10032.ORCID 0000-0003-4752-9123
Rudolph L LeibelColumbia University Medical Center, New York, NY 10032.ORCID 0000-0002-6062-7222
Columbia University Irving Medical Center · US

Funding

Translational Biomarker Analytical Core (TBAC)P30DK063608 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Anthony W Ferrante · 2003 to 2026
$36.7M
RESEARCH TRAININGP30DK026687 · NIDDK · ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS · PI Anthony W Ferrante, DYMPNA GALLAGHER · 1986 to 2026
$33.0M
Transgenic CoreP30DK046200 · NIDDK · TUFTS MEDICAL CENTER · PI CORKEY, BARBARA E. · 1992 to 2021
$25.0M
The molecular genetic analysis of human obesityR01DK052431 · NIDDK · ROCKEFELLER UNIVERSITY · PI CHUNG, WENDY K, LEIBEL, RUDOLPH L · 1996 to 2020
$11.6M
Functional imaging and eating behavior among FTO genotypes in pre-obese childrenR01DK097399 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAYER, LAUREL ES, ROSENBAUM, MICHAEL · 2013 to 2017
$2.9M
Becton Dickinson LSR II Analytical Flow CytometerS10RR027050 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CLYNES, RAPHAEL A. · 2011 to 2011
$413k
NCRR NIH HHS S10 RR027050NIDDK NIH HHS P30 DK026687NIDDK NIH HHS P30 DK046200NIDDK NIH HHS P30 DK063608NIDDK NIH HHS R01 DK052431NIDDK NIH HHS R01 DK097399
6 · The paper itself

Abstract

SNPs in the first intron of α-ketoglutarate-dependent dioxygenase (

Indexed as

3T3-L1 CellsAdenosineAdipocytesAdipogenesisAlpha-Ketoglutarate-Dependent Dioxygenase FTOAnimalsDNADNA MethylationExtracellular Matrix ProteinsGene Knockdown TechniquesLipid MetabolismMiceNeoplasm ProteinsPhosphorylationProto-Oncogene Proteins c-aktReceptor-Like Protein Tyrosine Phosphatases, Class 3AdenosineAlpha-Ketoglutarate-Dependent Dioxygenase FTODNAExtracellular Matrix ProteinsFTO protein, humanFTO protein, mouseNeoplasm ProteinsN-methyladenosineProto-Oncogene Proteins c-aktReceptor-Like Protein Tyrosine Phosphatases, Class 3SPON2 protein, humanadipose tissuediabetesgeneticsmessenger ribonucleic acidmethylationobesityα-ketoglutarate-dependent dioxygenase

Identifiers

PMID29934339
PMCPMC6071765
OpenAlexW2809001932

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.