Evidence map›Paper›PMID 29934306›Full record

ArticleThe Journal of biological chemistry2018

Disulfide-crosslink scanning reveals prion-induced conformational changes and prion strain-specific structures of the pathological prion protein PrP

Yuzuru Taguchi, Li Lu, Cristobal Marrero-Winkens, Hiroki Otaki, Noriyuki Nishida, Hermann M Schatzl

Erratum issuedOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. New developments in prion disease research.Cell and tissue research · 2023
    Article
  4. Vaccines for prion diseases: a realistic goal?Cell and tissue research · 2023
    Review
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Yuzuru TaguchiDepartment of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta T2N 4Z6, Canada; Department of Molecular Microbiology and Immunology, Division of Cellular and Molecular Biology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8523, Japan. Electronic address: ytaguchi@nagasaki-u.ac.jp.
Li LuDepartment of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta T2N 4Z6, Canada; Calgary Prion Research Unit, University of Calgary, Calgary, Alberta, Canada.
Cristobal Marrero-WinkensDepartment of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta T2N 4Z6, Canada; Calgary Prion Research Unit, University of Calgary, Calgary, Alberta, Canada.
Hiroki OtakiCenter for Bioinformatics and Molecular Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8523, Japan.
Noriyuki NishidaDepartment of Molecular Microbiology and Immunology, Division of Cellular and Molecular Biology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8523, Japan.
Hermann M SchatzlDepartment of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta T2N 4Z6, Canada; Calgary Prion Research Unit, University of Calgary, Calgary, Alberta, Canada. Electronic address: hschaetz@ucalgary.ca.
University of Calgary · CANagasaki University · JPUniversity of Nagasaki · JP

Funding

Elucidating the cellular mechanisms of prion propagation and clearance for devisiR01NS076853 · NINDS · UNIVERSITY OF WYOMING · PI JARVIS, DONALD L. · 2012 to 2016
$1.5M
NINDS NIH HHS R01 NS076853
6 · The paper itself

Abstract

Prions are composed solely of the pathological isoform (PrP

Indexed as

Protein ConformationAmino Acid SequenceAnimalsCross-Linking ReagentsDisulfidesHumansMiceNeuroblastomaPrionsPrPSc ProteinsScrapieSequence HomologyTumor Cells, CulturedCross-Linking ReagentsDisulfidesPrionsPrPSc Proteinsprionprion conversionprion diseaseprion proteinprotein conformationprotein crosslinkingprotein misfoldingprotein structure

Identifiers

PMID29934306
PMCPMC6102138
OpenAlexW2809578770

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.