ArticlePlant physiology2018
Two Tabersonine 6,7-Epoxidases Initiate Lochnericine-Derived Alkaloid Biosynthesis in
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Article in Plant physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18citing papers in PubMed
5.6field-weighted citation impact, top 4% of its field
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Who cites it
18 citing papers in PubMed, 51 citations in OpenAlex.
- Orthologue inference-based enzyme mining for diversification of the anti-cancer evodiamine scaffold.Communications chemistry · 2026Article
- Multi-combination comparative transcriptome analysis response to MeJA and identifies genes putatively involved in oridonin biosynthesis in Isodon rubescens.BMC plant biology · 2025Article
- Analysis of the Rehmannia chingii geneome identifies RcCYP72H7 as an epoxidase in iridoid glycoside biosynthesis.Nature communications · 2025Article
- Genome-based discovery of pachysiphine synthases in Tabernaemontana elegans.The Plant journal : for cell and molecular biology · 2024Article
- Oxidation of four monoterpenoid indole alkaloid classes by three cytochrome P450 monooxygenases from Tabernaemontana litoralis.The Plant journal : for cell and molecular biology · 2024Article
- Characterization of a vacuolar importer of secologanin in Catharanthus roseus.Communications biology · 2024Article
- Single-cell multi-omics in the medicinal plant Catharanthus roseus.Nature chemical biology · 2023Article
- Article
- Semi-syntheses and interrogation of indole-substitutedOrganic & biomolecular chemistry · 2022Article
- Hairy roots: An untapped potential for production of plant products.Frontiers in plant science · 2022Review
- Terpenoid indole alkaloid biosynthesis in Catharanthus roseus: effects and prospects of environmental factors in metabolic engineering.Biotechnology letters · 2021Review
- Improved virus-induced gene silencing allows discovery of a serpentine synthase gene in Catharanthus roseus.Plant physiology · 2021Article
- Optimization of Tabersonine Methoxylation to Increase Vindoline Precursor Synthesis in Yeast Cell Factories.Molecules (Basel, Switzerland) · 2021Article
- Cytochrome P450 Enzymes as Key Drivers of Alkaloid Chemical Diversification in Plants.Frontiers in plant science · 2021Review
- Subfunctionalization of Paralog Transcription Factors Contributes to Regulation of Alkaloid Pathway Branch Choice inFrontiers in plant science · 2021Article
- Identifying Genes Involved in alkaloid Biosynthesis inBiomolecules · 2020Article
- Developmental Methylome of the Medicinal PlantInternational journal of molecular sciences · 2020Article
- Mutually Regulated AP2/ERF Gene Clusters Modulate Biosynthesis of Specialized Metabolites in Plants.Plant physiology · 2020Article
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Authors and funding
25 authors at 4 institutions in 3 countries.
Inês CarqueijeiroUniversité de Tours, EA2106 Biomolécules et Biotechnologies Végétales, Tours, F-37200, France.ORCID 0000-0001-9576-5556
Stephanie BrownJohn Innes Centre, Department of Biological Chemistry, Norwich NR4 7UH, United Kingdom.
Khoa ChungJohn Innes Centre, Department of Biological Chemistry, Norwich NR4 7UH, United Kingdom.ORCID 0000-0002-1920-3663
Thu-Thuy DangJohn Innes Centre, Department of Biological Chemistry, Norwich NR4 7UH, United Kingdom.
Manish WaliaDepartment of Chemistry, Temple University, Philadelphia, Pennsylvania 19122, USA.ORCID 0000-0002-0028-802X
Sébastien BesseauUniversité de Tours, EA2106 Biomolécules et Biotechnologies Végétales, Tours, F-37200, France.ORCID 0000-0002-5518-2580
Thomas Dugé de BernonvilleUniversité de Tours, EA2106 Biomolécules et Biotechnologies Végétales, Tours, F-37200, France.ORCID 0000-0002-2205-2886
Audrey OudinUniversité de Tours, EA2106 Biomolécules et Biotechnologies Végétales, Tours, F-37200, France.
Arnaud LanoueUniversité de Tours, EA2106 Biomolécules et Biotechnologies Végétales, Tours, F-37200, France.ORCID 0000-0002-7377-8177
Kevin BilletUniversité de Tours, EA2106 Biomolécules et Biotechnologies Végétales, Tours, F-37200, France.
Thibaut MunschUniversité de Tours, EA2106 Biomolécules et Biotechnologies Végétales, Tours, F-37200, France.
Konstantinos KoudounasUniversité de Tours, EA2106 Biomolécules et Biotechnologies Végétales, Tours, F-37200, France.ORCID 0000-0002-6000-6565
Céline MelinUniversité de Tours, EA2106 Biomolécules et Biotechnologies Végétales, Tours, F-37200, France.
Charlotte GodonUniversité d'Angers, EA3142 Groupe d'Etude des Interactions Hôte-Pathogène, Angers, F-49933, France.
Bienvenue RazafimandimbyUniversité d'Angers, EA3142 Groupe d'Etude des Interactions Hôte-Pathogène, Angers, F-49933, France.
Johan-Owen de CraeneUniversité de Tours, EA2106 Biomolécules et Biotechnologies Végétales, Tours, F-37200, France.
Gaëlle GlévarecUniversité de Tours, EA2106 Biomolécules et Biotechnologies Végétales, Tours, F-37200, France.
Jillian MarcUniversité de Tours, EA2106 Biomolécules et Biotechnologies Végétales, Tours, F-37200, France.
Nathalie Giglioli-Guivarc'hUniversité de Tours, EA2106 Biomolécules et Biotechnologies Végétales, Tours, F-37200, France.
Marc ClastreUniversité de Tours, EA2106 Biomolécules et Biotechnologies Végétales, Tours, F-37200, France.
Benoit St-PierreUniversité de Tours, EA2106 Biomolécules et Biotechnologies Végétales, Tours, F-37200, France.ORCID 0000-0002-9077-2949
Nicolas PaponUniversité d'Angers, EA3142 Groupe d'Etude des Interactions Hôte-Pathogène, Angers, F-49933, France.
Rodrigo B AndradeDepartment of Chemistry, Temple University, Philadelphia, Pennsylvania 19122, USA.ORCID 0000-0002-4554-8323
Sarah E O'ConnorJohn Innes Centre, Department of Biological Chemistry, Norwich NR4 7UH, United Kingdom sarah.o'connor@jic.ac.uk vincent.courdavault@univ-tours.fr.
Vincent CourdavaultUniversité de Tours, EA2106 Biomolécules et Biotechnologies Végétales, Tours, F-37200, France sarah.o'connor@jic.ac.uk vincent.courdavault@univ-tours.fr.ORCID 0000-0001-8902-4532
Université de Tours · FRJohn Innes Centre · GBUniversité d'Angers · FRTemple University · US
Funding
European Research Council 311363
Abstract
Lochnericine is a major monoterpene indole alkaloid (MIA) in the roots of Madagascar periwinkle (
Indexed as
CatharanthusGene Expression Regulation, PlantGene SilencingIndole AlkaloidsIsoenzymesMetabolic EngineeringMicroorganisms, Genetically-ModifiedMixed Function OxygenasesPlant ProteinsPlant RootsSecologanin Tryptamine AlkaloidsYeastsIndole AlkaloidsIsoenzymeslochnericineMixed Function OxygenasesPlant ProteinsSecologanin Tryptamine Alkaloids
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.