Evidence map›Paper›PMID 29934071›Full record

ArticleDiagnostic microbiology and infectious disease2018

Evaluation of apramycin activity against methicillin-resistant, methicillin-sensitive, and vancomycin-intermediate Staphylococcus aureus clinical isolates.

Katherine A Truelson, Thea Brennan-Krohn, Kenneth P Smith, James E Kirby

Abstract read
In one paragraph

Article in Diagnostic microbiology and infectious disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Synthesis of 4-Tetrahedron · 2023
    Article
  5. Article
  6. Synthesis, Antibacterial and Antiribosomal Activity of the 3Antibiotics (Basel, Switzerland) · 2022
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Apralogs: Apramycin 5-Journal of the American Chemical Society · 2020
    Article
  13. Frontiers in microbiology · 2020
    Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Katherine A TruelsonBoston University, Boston, MA, USA.
Thea Brennan-KrohnDepartment of Pathology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Kenneth P SmithDepartment of Pathology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
James E KirbyDepartment of Pathology, Beth Israel Deaconess Medical Center, Boston, MA, USA. Electronic address: jekirby@bidmc.harvard.edu.

Funding

INFECTIOUS DISEASE AND BASIC MICROBIOLOGICAL MECHANISMST32AI007061 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Marcia B Goldberg · 1985 to 2026
$12.1M
Antimicrobial Synergy for Carbapenem-Resistant Enterobacteriaceae - Administrative SupplementK08AI132716 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI BRENNAN-KROHN, THEA · 2018 to 2022
$916k
Identification and Characterization of Novel Antimicrobial Adjunctives to Restore Susceptibility to Carbapenem Resistant EnterobacteriaceaeF32AI124590 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SMITH, KENNETH PATRICK · 2017 to 2019
$175k
NIAID NIH HHS F32 AI124590NIAID NIH HHS K08 AI132716NIAID NIH HHS T32 AI007061
6 · The paper itself

Abstract

We evaluated the in vitro activity of apramycin against clinical strains of vancomycin-intermediate and methicillin-resistant and -susceptible Staphylococcus aureus. Apramycin demonstrated an MIC

Indexed as

Anti-Bacterial AgentsHumansMethicillinMethicillin ResistanceNebramycinStaphylococcal InfectionsStaphylococcus aureusVancomycinAnti-Bacterial AgentsapramycinMethicillinNebramycinVancomycinActivity spectrumAminoglycosideAntibioticApramycinGentamicinNatural productRepurposingStaphylococcus aureusSynergy

Identifiers

PMID29934071
PMCPMC6131043

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.