ArticleJournal of neuroinflammation2018
Effects of chronic noise exposure on the microbiome-gut-brain axis in senescence-accelerated prone mice: implications for Alzheimer's disease.
Article in Journal of neuroinflammation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed, 104 citations in OpenAlex.
- Influence of sound vibrations on plant holobionts: physiological pathways linking root function and rhizospheric microbial interactions.Plant signaling & behavior · 2026Review
- Review
- Interactions Between Perioperative Anesthesia Management and Gut Microbiota: Current Research Advances.Cellular and molecular neurobiology · 2026Review
- Complex multisource sound induces greater neurodegeneration in neonatal rat brain than single-source sound.Frontiers in systems neuroscience · 2026Article
- Gut Resistome and Hearing Loss in Young Adults: A Preliminary Study on the Interplay Between Microbial Resistance and Auditory Health.Antibiotics (Basel, Switzerland) · 2025Article
- Effects of noise pollution in construction workers.Medicine · 2025Observational
- The gut feeling in motion sickness.Communications biology · 2025Review
- Intestinal inflammation and microbiota modulation impact cochlear function: emerging insights in gut-ear axis.Cell communication and signaling : CCS · 2025Article
- Fecal microbiota transplantation in allergic diseases.World journal of methodology · 2025Review
- Around-the-clock noise exposure induces hippocampus apoptosis and subsequent cognitive impairment via the PI3K/SGK1/Foxo3 signaling pathway.Journal of translational medicine · 2025Article
- Nrf2 deficiency enhances oxidative stress and promotes susceptibility to tinnitus in mice.Scientific reports · 2025Article
- Fructooligosaccharides and Aspergillus enzymes increase brain GABA and homocarnosine by modulating microbiota in adolescent mice.NPJ science of food · 2025Article
- Microbiota-indole-3-propionic acid-heart axis mediates the protection of leflunomide against αPD1-induced cardiotoxicity in mice.Nature communications · 2025Article
- A Mendelian Randomization Study of the Association Between Loud Music Exposure Frequency and Anxiety Disorders in European Populations.Neuropsychiatric disease and treatment · 2025Article
- Superparamagnetic iron oxide nanoparticle regulates microbiota-gut-inner ear axis for hearing protection.National science review · 2024Article
- Examining Sound, Light, and Vibrations as Tools to Manage Microbes and Support Holobionts, Ecosystems, and Technologies.Microorganisms · 2024Review
- Crosstalk between Oxidative Stress and Inflammation Caused by Noise and Air Pollution-Implications for Neurodegenerative Diseases.Antioxidants (Basel, Switzerland) · 2024Review
- Effects of Astragaloside IV on Hearing, Inflammatory Factors, and Intestinal Flora in Mice Exposed to Noise.Metabolites · 2024Article
- Health position paper and redox perspectives - Disease burden by transportation noise.Redox biology · 2024Review
- Impact of Altered Gut Microbiota on Ketamine-Induced Conditioned Place Preference in Mice.Neuropsychiatric disease and treatment · 2024Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic noise exposure is associated with neuroinflammation and gut microbiota dysregulation and increases the risk of Alzheimer's disease (AD). Environmental hazards are also thought to be associated with genetic susceptibility factors that increase AD pathogenesis. However, there is limited experimental evidence regarding the link between chronic noise stress and microbiome-gut-brain axis alterations, which may be closely related to AD development.
methodsThe aim of the present study was to systematically investigate the effects of chronic noise exposure on the microbiome-gut-brain axis in the senescence-accelerated mouse prone 8 (SAMP8) strain. We established SAMP8 mouse models to examine the consequences of noise exposure on the microbiome-gut-brain axis. Hippocampal amyloid-β (Aβ) assessment and the Morris water maze were used to evaluate AD-like changes, 16S ribosomal RNA sequencing analyses were used for intestinal flora measurements, and assessment of endothelial tight junctions and serum neurotransmitter and inflammatory mediator levels, as well as fecal microbiota transplant, was conducted to explore the underlying pathological mechanisms.
resultsChronic noise exposure led to cognitive impairment and Aβ accumulation in young SAMP8 mice, similar to that observed in aging SAMP8 mice. Noise exposure was also associated with decreased gut microbiota diversity and compositional alterations. Axis-series studies showed that endothelial tight junction proteins were decreased in both the intestine and brain, whereas serum neurotransmitter and inflammatory mediator levels were elevated in young SAMP8 mice exposed to chronic noise, similar to the observations made in the aging group. The importance of intestinal bacteria in noise exposure-induced epithelial integrity impairment and Aβ accumulation was further confirmed through microbiota transplantation experiments. Moreover, the effects of chronic noise were generally intensity-dependent.
conclusionChronic noise exposure altered the gut microbiota, accelerated age-related neurochemical and inflammatory dysregulation, and facilitated AD-like changes in the brain of SAMP8 mice.
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