ReviewDiagnostics (Basel, Switzerland)2018
Neural Indicators of Fatigue in Chronic Diseases: A Systematic Review of MRI Studies.
Review in Diagnostics (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Brain connectivity changes underlying depression and fatigue in relapsing-remitting multiple sclerosis: A systematic review.PloS one · 2024Pooled it
- Resting state brain connectivity of pain and fatigue is affected by performance of a fatiguing attention task in patients with chronic pain.Neuroimage. Reports · 2026Article
- Recommendations for cancer related fatigue in post-treatment survivorship care: a cross-sectional analysis of guidelines.Journal of cancer survivorship : research and practice · 2026Review
- Volume and distribution of white matter hyperintensities in rheumatoid arthritis and ulcerative colitis patients.Scientific reports · 2024Article
- Effect of Post-COVID-19 on Brain Volume and Glucose Metabolism: Influence of Time Since Infection and Fatigue Status.Brain sciences · 2023Article
- A Multi-Dimensional Model of Fatigue in Old Age: Implications for Brain Aging.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2023Article
- Brain Small-Worldness Properties and Perceived Fatigue in Mild Cognitive Impairment.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Article
- Fatigue in inflammatory rheumatic diseases: current knowledge and areas for future research.Nature reviews. Rheumatology · 2021Review
- Altered in vivo brain GABA and glutamate levels are associated with multiple sclerosis central fatigue.European journal of radiology · 2021Article
- The Gut Microbiome in Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS).Frontiers in immunology · 2021Review
- Brain structural connectomes indicate shared neural circuitry involved in subjective experience of cognitive and physical fatigue in older adults.Brain imaging and behavior · 2020Article
- Evidence of widespread metabolite abnormalities in Myalgic encephalomyelitis/chronic fatigue syndrome: assessment with whole-brain magnetic resonance spectroscopy.Brain imaging and behavior · 2020Article
- Association between fatigue, motivational measures (BIS/BAS) and semi-structured psychosocial interview in hemodialytic treatment.BMC psychology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While fatigue is prevalent in chronic diseases, the neural mechanisms underlying this symptom remain unknown. Magnetic resonance imaging (MRI) has the potential to enable us to characterize this symptom. The aim of this review was to gather and appraise the current literature on MRI studies of fatigue in chronic diseases. We systematically searched the following databases: MedLine, PsycInfo, Embase and Scopus (inception to April 2016). We selected studies according to a predefined inclusion and exclusion criteria. We assessed the quality of the studies and conducted descriptive statistical analyses. We identified 26 studies of varying design and quality. Structural and functional MRI, alongside diffusion tensor imaging (DTI) and functional connectivity (FC) studies, identified significant brain indicators of fatigue. The most common regions were the frontal lobe, parietal lobe, limbic system and basal ganglia. Longitudinal studies offered more precise and reliable analysis. Brain structures found to be related to fatigue were highly heterogeneous, not only between diseases, but also for different studies of the same disease. Given the different designs, methodologies and variable results, we conclude that there are currently no well-defined brain indicators of fatigue in chronic diseases.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.