Evidence map›Paper›PMID 29933637›Full record

ArticleMolecules (Basel, Switzerland)2018

Proanthocyanidins Protect Epithelial Cells from Zearalenone-Induced Apoptosis via Inhibition of Endoplasmic Reticulum Stress-Induced Apoptosis Pathways in Mouse Small Intestines.

Miao Long, Xinliang Chen, Nan Wang, Mingyang Wang, Jiawen Pan, Jingjing Tong, Peng Li, Shuhua Yang, Jianbin He

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
5.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 39 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Miao LongKey Laboratory of Zoonosis of Liaoning Province, College of Animal Science & Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China. longjlau@126.com.ORCID 0000-0001-5332-8761
Xinliang ChenKey Laboratory of Zoonosis of Liaoning Province, College of Animal Science & Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China. 20152529@stu.syau.edu.cn.
Nan WangKey Laboratory of Zoonosis of Liaoning Province, College of Animal Science & Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China. LCwangnan@163.com.
Mingyang WangKey Laboratory of Zoonosis of Liaoning Province, College of Animal Science & Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China. m13940546231@163.com.
Jiawen PanKey Laboratory of Zoonosis of Liaoning Province, College of Animal Science & Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China. panjiawen0101@163.com.
Jingjing TongKey Laboratory of Zoonosis of Liaoning Province, College of Animal Science & Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China. m18641260406_1@163.com.
Peng LiKey Laboratory of Zoonosis of Liaoning Province, College of Animal Science & Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China. lipeng79625@163.com.
Shuhua YangKey Laboratory of Zoonosis of Liaoning Province, College of Animal Science & Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China. yangshuhua0001@126.com.
Jianbin HeKey Laboratory of Zoonosis of Liaoning Province, College of Animal Science & Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China. hejianbin69@163.com.
Shenyang Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study evaluated the protective effect of proanthocyanidins (PCs) on reducing apoptosis in the mouse intestinal epithelial cell model MODE-K exposed to zearalenone (ZEA) through inhibition of the endoplasmic reticulum stress (ERS)-induced apoptosis pathway. Our results showed that PCs could reduce the rate of apoptosis in MODE-K cells exposed to ZEA (

Indexed as

AnimalsAntioxidantsApoptosisbcl-2-Associated X ProteinCaspase 12Cell LineCell SurvivalEndoplasmic Reticulum Chaperone BiPEndoplasmic Reticulum StressEpithelial CellsEstrogens, Non-SteroidalGene Expression RegulationGlutathioneGlutathione PeroxidaseHeat-Shock ProteinsIntestine, SmallAntioxidantsBax protein, mousebcl-2-Associated X ProteinBcl2 protein, mouseCasp12 protein, mouseCaspase 12Ddit3 protein, mouseEndoplasmic Reticulum Chaperone BiPEstrogens, Non-SteroidalGlutathioneGlutathione PeroxidaseHeat-Shock ProteinsHspa5 protein, mouseJNK Mitogen-Activated Protein KinasesMalondialdehydeProanthocyanidinsProto-Oncogene Proteins c-bcl-2Superoxide DismutaseTranscription Factor CHOPZearalenoneapoptosisendoplasmic reticulum stressintestinal epithelial cellsmiceoxidative damageproanthocyanidinszearalenone

Identifiers

PMID29933637
PMCPMC6099583
OpenAlexW2809187792

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.