ArticlePloS one2018
2,4-dichlorophenoxyacetic acid-induced oxidative stress: Metabolome and membrane modifications in Umbelopsis isabellina, a herbicide degrader.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 59 citations in OpenAlex.
- Shared Plant-human Biology: Herbicide Effects and New Biomarkers Perspectives.Current environmental health reports · 2026Review
- Evolutionary diversity of sphingolipid metabolism proteins in fungi.IMA fungus · 2026Article
- 2,4-Dichlorophenoxyacetic acid herbicide degradation by isolated bacterial species from termite mound soil in Ethiopia.BMC microbiology · 2025Article
- Synergistic Activity ofInternational journal of molecular sciences · 2025Article
- Pesticides have negative effects on non-target organisms.Nature communications · 2025Article
- Antimicrobial and antiproliferative activity of biosynthesized manganese nanocomposite with amide derivative originated by endophytic Aspergillus terreus.Microbial cell factories · 2025Article
- Microorganism-Driven 2,4-D Biodegradation: Current Status and Emerging Opportunities.Molecules (Basel, Switzerland) · 2024Review
- Article
- Herbicide 2,4-dichlorophenoxyacetic acid interferes with MAP kinase signaling in Fusarium graminearum and is inhibitory to fungal growth and pathogenesis.Stress biology · 2023Article
- Article
- Deciphering the recent trends in pesticide bioremediation using genome editing and multi-omics approaches: a review.World journal of microbiology & biotechnology · 2023Review
- Combined Application of Aminoglycosides and Ascorbic Acid in the Elimination ofInternational journal of molecular sciences · 2022Article
- Accelerated PAH Transformation in the Presence of Dye Industry Landfill Leachate Combined with Fungal Membrane Lipid Changes.International journal of environmental research and public health · 2022Article
- Microplastic-Induced Oxidative Stress in Metolachlor-Degrading Filamentous FungusInternational journal of molecular sciences · 2022Article
- A Common Feature of Pesticides: Oxidative Stress-The Role of Oxidative Stress in Pesticide-Induced Toxicity.Oxidative medicine and cellular longevity · 2022Review
- Synthesis of Dolichols inInternational journal of molecular sciences · 2021Article
- Bisphenol A Removal by the FungusInternational journal of molecular sciences · 2021Article
- Phospholipids and Fatty Acids Affect the Colonization of Urological Catheters byInternational journal of molecular sciences · 2021Article
- Integrated Metabolomics and Targeted Gene Transcription Analysis Reveal Global Bacterial Antimonite Resistance Mechanisms.Frontiers in microbiology · 2021Article
- Metabolic Potential, Ecology and Presence of Associated Bacteria Is Reflected in Genomic Diversity of Mucoromycotina.Frontiers in microbiology · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The study reports the response to herbicide of the 2,4-dichlorophenoxyacetic acid (2,4-D)-degrading fungal strain Umbelopsis isabellina. A comparative analysis covered 41 free amino acids as well as 140 lipid species of fatty acids, phospholipids, acylglycerols, sphingolipids, and sterols. 2,4-D presence led to a decrease in fungal catalase activity, associated with a higher amount of thiobarbituric acid-reactive substances (TBARS). Damage to cells treated with the herbicide resulted in increased membrane permeability and decreased membrane fluidity. Detailed lipidomic profiling showed changes in the fatty acids composition such as an increase in the level of linoleic acid (C18:2). Moreover, an increase in the phosphatidylethanolamine/phosphatidylcholine ratio was observed. Analysis of fungal lipid profiles revealed that the presence of 2,4-D was accompanied by the accumulation of triacylglycerols, a decrease in ergosterol content, and a considerable rise in the level of sphingolipid ceramides. In the exponential phase of growth, increased levels of leucine, glycine, serine, asparagine, and hydroxyproline were found. The results obtained in our study confirmed that in the cultures of U. isabellina oxidative stress was caused by 2,4-D. The herbicide itself forced changes not only to membrane lipids but also to neutral lipids and amino acids, as the difference of tested compounds profiles between 2,4-D-containing and control samples was consequently lower as the pesticide degradation progressed. The presented findings may have a significant impact on the basic understanding of 2,4-D biodegradation and may be applied for process optimization on metabolomic and lipidomic levels.
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