ArticlePloS one2018
Lactobacillus murinus HF12 colonizes neonatal gut and protects rats from necrotizing enterocolitis.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 45 citations in OpenAlex.
- Synergistic regulation of gut microbiota and metabolites by breast milk and probiotics in the prevention of neonatal necrotizing enterocolitis: mechanisms and prospects.Translational pediatrics · 2026Review
- Integrated Multi-Omics Analyses Identify Acupuncture-Associated Changes in Gut Microbiota, Short-Chain Fatty Acids, and TNC Gene Expression in Chronic Migraine Rats.Journal of inflammation research · 2026Article
- The impact of co-fed plastic diet on Tenebrio molitor gut bacterial community structure.Scientific reports · 2025Article
- Crosstalk between gut microbiota and tumor: tumors could cause gut dysbiosis and metabolic imbalance.Molecular oncology · 2025Article
- Muscone Ameliorates High-Altitude Hypoxia Gastrointestinal Stress via Modulation of Lactobacillus Murinus and Mitochondrial Metabolism.Journal of inflammation research · 2025Article
- Unveiling the potential ofFrontiers in microbiology · 2025Review
- Fasting-mimicking diet remodels gut microbiota and suppresses colorectal cancer progression.NPJ biofilms and microbiomes · 2024Article
- Human-derived bacterial strains mitigate colitis via modulating gut microbiota and repairing intestinal barrier function in mice.BMC microbiology · 2024Article
- Rat microbial biogeography and age-dependent lactic acid bacteria in healthy lungs.Lab animal · 2024Article
- Effects of hydroxychloroquine on the mucosal barrier and gut microbiota during healing of mice colitis.American journal of translational research · 2024Article
- β-glucan protects against necrotizing enterocolitis in mice by inhibiting intestinal inflammation, improving the gut barrier, and modulating gut microbiota.Journal of translational medicine · 2023Article
- Host species and habitats shape the bacterial community of gut microbiota of three non-human primates: Siamangs, white-handed gibbons, and Bornean orangutans.Frontiers in microbiology · 2022Article
- Effect of the Microbiome on Intestinal Innate Immune Development in Early Life and the Potential Strategy of Early Intervention.Frontiers in immunology · 2022Review
- Deficiency of migration inhibitory factor influences the gut microbiota of C57BL/6 mice infected withFrontiers in microbiology · 2022Article
- Immunoglobulin A, an Active Liaison for Host-Microbiota Homeostasis.Microorganisms · 2021Review
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- Age- and duration-dependent effects of whey protein on high-fat diet-induced changes in body weight, lipid metabolism, and gut microbiota in mice.Physiological reports · 2020Article
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- Molecular Phenotyping and Genomic Characterization of a Novel Neuroactive Bacterium Strain,Frontiers in pharmacology · 2019Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
The use of lactobacilli in prevention of necrotizing enterocolitis (NEC) is hampered by insufficient knowledge about optimal species/strains and effects on intestinal bacterial populations. We therefore sought to identify lactobacilli naturally occurring in postnatal rats and examine their ability to colonize the neonatal intestine and protect from NEC. L. murinus, L. acidophilus, and L. johnsonii were found in 42, 20, and 1 out of 51 4-day old rats, respectively. Higher proportion of L. murinus in microbiota correlated with lower NEC scores. Inoculation with each of the three species during first feeding significantly augmented intestinal populations of lactobacilli four days later, indicating successful colonization. L. murinus, but not L. acidophilus or L. johnsonii, significantly protected against NEC. Thus, lactobacilli protect rats from NEC in a species- or strain-specific manner. Our results may help rationalizing probiotic therapy in NEC.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.