ArticleMedicine and science in sports and exercise2018
Handgrip Strength, Function, and Mortality in Older Adults: A Time-varying Approach.
Article in Medicine and science in sports and exercise, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Purpose in life and grip strength: An individual-participant meta-analysis of 115,972 participants from 24 countries across four continents.GeroScience · 2025Pooled it
- Oral function and physical function converge: national evidence linking functional teeth, scaling care, and muscle strength.BMC geriatrics · 2026Article
- Functional fitness tests and their association with upper-limb isokinetic strength in older adults.Aging clinical and experimental research · 2026Article
- Article
- GLP-1 receptor agonist therapy and skeletal muscle: A narrative review synthesizing adult evidence with implications for older adults.JAR life · 2026Review
- Toe Grip Strength Shows Stronger Associations with Falls than Knee Extension or Hand Grip in Older Adults: A 1-year Prospective Cohort Study.Progress in rehabilitation medicine · 2026Article
- Effects of reablement on home-dwelling older adults' physical functioning: a quasi-experimental study in primary healthcare.Aging clinical and experimental research · 2025Article
- Cumulative handgrip strength and longitudinal changes in cognitive function and daily functioning among people aged 50 years and older: evidence from two longitudinal cohort studies.Archives of public health = Archives belges de sante publique · 2025Article
- Article
- Relationship between sarcopenia and cardiovascular disease among middle-aged and older adults with normal weight in China: functional limitation plays a mediating role.Environmental health and preventive medicine · 2025Article
- Collective Weakness and Fluidity in Weakness Status Associated With Basic Self-Care Limitations in Older Americans.American journal of medicine open · 2024Article
- Association of Serum Concentrations of Copper, Selenium, and Zinc with Grip Strength Based on NHANES 2013-2014.Biological trace element research · 2024Article
- Correlation of muscle strength, working memory, and activities of daily living in older adults.Frontiers in aging neuroscience · 2024Article
- Prevalence and Trends of Basic Activities of Daily Living Limitations in Middle-Aged and Older Adults in the United States.Epidemiologia (Basel, Switzerland) · 2023Article
- Criterion-Referenced Standards of Handgrip Strength for Identifying the Presence of Hypertension in Croatian Older Adults.Journal of clinical medicine · 2023Article
- One-Year Handgrip Strength Change in Kindergarteners Depends upon Physical Activity Status.Life (Basel, Switzerland) · 2023Article
- Association of Salt Intake with Muscle Strength and Physical Performance in Middle-Aged to Older Chinese: The Guangzhou Biobank Cohort Study.Nutrients · 2023Article
- Bidirectional association between handgrip strength and ADLs disability: a prospective cohort study.Frontiers in public health · 2023Article
- Association among race/color, gender, and intrinsic capacity: results from the ELSI-Brazil study.Revista de saude publica · 2023Article
- Children with Low Handgrip Strength: A Narrative Review of Possible Exercise Strategies to Improve Its Development.Children (Basel, Switzerland) · 2022Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
purposeTo determine the time-varying associations between 1) decreased handgrip strength and disabilities in each activity of daily living (ADL) function, and 2) disaggregated ADL limitations and time to mortality in older adults.
methodsA United States nationally representative sample of 17,747 older adults from the Health and Retirement Study were followed up for 8 yr. Maximal handgrip strength was measured with a hand-held dynamometer. Ability to perform ADL was self-reported. Date of death was identified by the National Death Index and exit interviews. Separate covariate-adjusted hierarchical logit models were used to examine the time-varying associations between decreased handgrip strength and each ADL outcome. Distinct covariate-adjusted Cox models were used to analyze the time-varying associations between disaggregated ADL limitations and time to mortality.
resultsEvery 5-kg decrease in handgrip strength was associated with increased odds for the following ADL limitations: 20% for eating, 14% for walking, 14% for bathing, 9% for dressing, 8% for transferring, and 6% for toileting. The presence of a bathing, walking, toileting, eating, and dressing ADL disability was associated with a 47%, 43%, 32%, 30%, and 19% higher hazard for mortality, respectively. A transferring ADL disability was not significantly associated with mortality.
conclusionsDecreased handgrip strength was associated with increased odds for each ADL limitation, and in turn, most individual ADL impairments were associated with a higher hazard for mortality in older adults. These findings provide insights into the disabling process by identifying which ADL limitations are most impacted by decreased handgrip strength and the subsequent time to mortality for each ADL disability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.