Evidence map›Paper›PMID 29932939›Full record

ArticleJournal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons2018

Nonsurgical Management of Medication-Related Osteonecrosis of the Jaws Using Local Wound Care.

Danny Hadaya, Akrivoula Soundia, Earl Freymiller, Tristan Grogan, David Elashoff, Sotirios Tetradis, Tara L Aghaloo

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
  2. Article
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  5. How we manage medication-related osteonecrosis of the jaw.European journal of medical research · 2024
    Review
  6. Article
  7. Article
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  9. Risk comparison of osteonecrosis of the jaw in osteoporotic patients treated with bisphosphonates vs. denosumab: a multi-institutional retrospective cohort study in Taiwan.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023
    Article
  10. Article
  11. Review
  12. Observational
  13. Bone Concentration of Ampicillin/Sulbactam: A Pilot Study in Patients with Osteonecrosis of the Jaw.International journal of environmental research and public health · 2022
    Article
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  15. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Danny HadayaPhD Student, Division of Diagnostic and Surgical Sciences, UCLA School of Dentistry, Los Angeles, CA.
Akrivoula SoundiaOral and Maxillofacial Radiology Resident, Division of Diagnostic and Surgical Sciences, UCLA School of Dentistry, Los Angeles, CA.
Earl FreymillerProfessor of Clinical Dentistry, Chair of Division of Diagnostic and Surgical Sciences, Chair of Section of Oral and Maxillofacial Surgery, Residency Program Director, and Bob and Marion Wilson Endowed Chair, UCLA School of Dentistry, Los Angeles, CA.
Tristan GroganPrincipal Statistician, Department of Medicine Statistics Core, UCLA David Geffen School of Medicine, Los Angeles, CA.
David ElashoffProfessor, Department of Biostatistics and Department of Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA.
Sotirios TetradisProfessor and Senior Associate Dean, Section of Oral and Maxillofacial Radiology, Division of Diagnostic and Surgical Sciences UCLA School of Dentistry, Los Angeles, CA. Electronic address: stetradis@dentistry.ucla.edu.
Tara L AghalooProfessor and Assistant Dean for Clinical Research, Section of Oral and Maxillofacial Surgery, Division of Diagnostic and Surgical Sciences, UCLA School of Dentistry, Los Angeles, CA. Electronic address: taghaloo@dentistry.ucla.edu.
University of California, Los Angeles · USUCLA Medical Center · US

Funding

UCLA FUNDAMENTAL CLINICAL RESEARCH TRAINING PROGRAMT32DE007296 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WONG, DAVID T · 1996 to 2011
$5.8M
Pathophysiologic Mechanisms of Bisphosphonate Related Osteonecrosis of the JawsR01DE019465 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TETRADIS, SOTIRIOS · 2009 to 2024
$5.4M
UCLA Dentist-Scientist and Oral Health-Researcher Training ProgramT90DE022734 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WONG, DAVID T · 2012 to 2017
$2.3M
Salivary Biomarkers in the Diagnosis of BRONJK02DE021444 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AGHALOO, TARA L · 2011 to 2013
$347k
Defining the transcriptome in Osteonecrosis of the JawsF30DE028171 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HADAYA, DANNY ELIAS · 2018 to 2019
$78k
NIDCR NIH HHS F30 DE028171NIDCR NIH HHS K02 DE021444NIDCR NIH HHS R01 DE019465NIDCR NIH HHS T32 DE007296NIDCR NIH HHS T90 DE022734
6 · The paper itself

Abstract

purposeMedication-related osteonecrosis of the jaws (MRONJ) is a known complication of antiresorptive medications with surgical and nonsurgical treatment options. The aim of this study was to evaluate the effectiveness of nonsurgical therapy using local wound care on management of MRONJ lesions. MATERIALS AND

methodsThe authors conducted a retrospective cohort study of patients who presented to the University of California-Los Angeles School of Dentistry Oral and Maxillofacial Surgery Clinic for evaluation and treatment of MRONJ. The primary predictor variable was wound care score; secondary predictors were demographics (age, gender), anatomic location, primary condition, and type and time of antiresorptive treatment. Outcomes assessed were disease resolution and time to disease resolution. Statistical analysis was carried out using the Spearman correlation for continuous and ordinal variables or the χ

resultsOne hundred six patients with 117 MRONJ lesions were treated using local wound care; complete disease resolution was observed 71% of lesions, with an additional 22% of lesions undergoing disease improvement. Wound care score was statistically associated with disease resolution and time to resolution, whereas demographics, anatomic site, condition, and type and time of antiresorptive treatment had no effect on resolution.

conclusionLocal wound care increased the likelihood of MRONJ resolution and decreased the time to disease resolution. This strategy can be used in patients who cannot undergo surgery and should be implemented in all patients with MRONJ lesions who are managed nonsurgically.

Indexed as

AgedAnti-Bacterial AgentsAnti-Infective Agents, LocalBisphosphonate-Associated Osteonecrosis of the JawChlorhexidineCombined Modality TherapyDebridementFemaleHumansMaleRetrospective StudiesTreatment OutcomeWound HealingAnti-Bacterial AgentsAnti-Infective Agents, LocalChlorhexidine

Identifiers

PMID29932939
PMCPMC6265090
OpenAlexW2805614019

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.