Evidence map›Paper›PMID 29932903›Full record

ArticleMolecular cell2018

Structures of Bacterial RNA Polymerase Complexes Reveal the Mechanism of DNA Loading and Transcription Initiation.

Robert Glyde, Fuzhou Ye, Milija Jovanovic, Ioly Kotta-Loizou, Martin Buck, Xiaodong Zhang

Abstract read
In one paragraph

Article in Molecular cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

  1. Comparative Characterization of σInternational journal of molecular sciences · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Real-time capture of σNature communications · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Structural basis of σProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  11. A general mechanism for transcription bubble nucleation in bacteria.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Robert GlydeSection of Structural Biology, Department of Medicine, Imperial College London, London SW7 2AZ, UK.
Fuzhou YeSection of Structural Biology, Department of Medicine, Imperial College London, London SW7 2AZ, UK.
Milija JovanovicDepartment of Life Sciences, Imperial College London, London SW7 2AZ, UK.
Ioly Kotta-LoizouDepartment of Life Sciences, Imperial College London, London SW7 2AZ, UK.
Martin BuckDepartment of Life Sciences, Imperial College London, London SW7 2AZ, UK.
Xiaodong ZhangSection of Structural Biology, Department of Medicine, Imperial College London, London SW7 2AZ, UK. Electronic address: xiaodong.zhang@imperial.ac.uk.

Funding

Biotechnology and Biological Sciences Research Council BB/H012249/1Biotechnology and Biological Sciences Research Council BB/N007816Medical Research Council MR/N006828/1Wellcome Trust
6 · The paper itself

Abstract

Gene transcription is carried out by multi-subunit RNA polymerases (RNAPs). Transcription initiation is a dynamic multi-step process that involves the opening of the double-stranded DNA to form a transcription bubble and delivery of the template strand deep into the RNAP for RNA synthesis. Applying cryoelectron microscopy to a unique transcription system using σ

Indexed as

BacteriaCryoelectron MicroscopyDNADNA, BacterialDNA-Directed RNA PolymerasesEscherichia coliModels, MolecularPromoter Regions, GeneticProtein BindingProtein ConformationSigma FactorTranscription, GeneticTranscription Initiation, GeneticTranscription Initiation SiteDNADNA, BacterialDNA-Directed RNA PolymerasesSigma Factorbacterial enhancer-binding proteinsde novo RNA synthesisDNA openingpromoter DNAprotein-DNA interactionsRNA polymerasesigmatranscription activationtranscription bubbletranscription initiation

Identifiers

PMID29932903
PMCPMC6028918

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.