Evidence map›Paper›PMID 29932867›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2019

Deletion of muscle IGF-I transiently impairs growth and progressively disrupts glucose homeostasis in male mice.

Georgios Vassilakos, Hanqin Lei, Yun Yang, Jason Puglise, Michael Matheny, Julia Durzynska, Matan Ozery, Katherine Bennett, Ray Spradlin, Heather Bonanno and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Insulin-like growth factor receptor signaling in physiology and disease.Signal transduction and targeted therapy · 2026
    Review
  2. Article
  3. Reduced Dietary Protein Induces Changes in the Dental Proteome.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2026
    Article
  4. Review
  5. Review
  6. Ablation of specific insulin-like growth factor I forms reveals the importance of cleavage for regenerative capacity and glycosylation for skeletal muscle storage.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
    Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. A synonymous mutation inMolecular therapy. Nucleic acids · 2021
    Article
  15. Actions and interactions of IGF-I and MMPs during muscle regeneration.Seminars in cell & developmental biology · 2021
    Review
  16. Review
  17. Deletion of muscleJournal of applied physiology (Bethesda, Md. : 1985) · 2021
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Georgios VassilakosApplied Physiology and Kinesiology, College of Health and Human Performance, University of Florida, Gainesville, Florida, USA.
Hanqin LeiApplied Physiology and Kinesiology, College of Health and Human Performance, University of Florida, Gainesville, Florida, USA.
Yun YangPharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, Florida, USA.
Jason PugliseApplied Physiology and Kinesiology, College of Health and Human Performance, University of Florida, Gainesville, Florida, USA.
Michael MathenyPharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, Florida, USA.
Julia DurzynskaApplied Physiology and Kinesiology, College of Health and Human Performance, University of Florida, Gainesville, Florida, USA.
Matan OzeryApplied Physiology and Kinesiology, College of Health and Human Performance, University of Florida, Gainesville, Florida, USA.
Katherine BennettApplied Physiology and Kinesiology, College of Health and Human Performance, University of Florida, Gainesville, Florida, USA.
Ray SpradlinApplied Physiology and Kinesiology, College of Health and Human Performance, University of Florida, Gainesville, Florida, USA.
Heather BonannoAnimal Care Services, Cancer and Genetics Research Complex, University of Florida, Gainesville, Florida, USA.
Soohyun ParkInstitute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas, USA.
Rexford S AhimaDivision of Endocrinology, Diabetes and Metabolism, Johns Hopkins University, Baltimore, Maryland, USA.
Elisabeth R BartonApplied Physiology and Kinesiology, College of Health and Human Performance, University of Florida, Gainesville, Florida, USA.

Funding

VIRAL VECTOR COREP30DK019525 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI MITCHELL A. LAZAR · 1986 to 2026
$48.3M
Training and education CoreU54AR052646 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI MCNALLY, ELIZABETH M, SWEENEY, H LEE · 2005 to 2020
$24.1M
Modulation of Muscle Regenerationby Growth FactorsR01AR057363 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI BARTON, ELISABETH R · 2010 to 2014
$1.4M
NIAMS NIH HHS R01 AR057363NIAMS NIH HHS U54 AR052646NIDDK NIH HHS P30 DK019525
6 · The paper itself

Abstract

Insulin-like growth factors (IGFs) are essential for local skeletal muscle growth and organismal physiology, but these actions are entwined with glucose homeostasis through convergence with insulin signaling. The objective of this work was to determine whether the effects of IGF-I on growth and metabolism could be separated. We generated muscle-specific IGF-I-deficient (MID) mice that afford inducible deletion of Igf1 at any age. After Igf1 deletion at birth or in young adult mice, evaluations of muscle physiology and glucose homeostasis were performed up to 16 wk of age. MID mice generated at birth had lower muscle and circulating IGF-I, decreased muscle and body mass, and impaired muscle force production. Eight-wk-old male MID had heightened insulin levels with trends of elevated fasting glucose. This phenotype progressed to impaired glucose handling and increased fat deposition without significant muscle mass loss at 16 wk of age. The same phenotype emerged in 16-wk-old MID mice induced at 12 wk of age, compounded with heightened muscle fatigability and exercise intolerance. We assert that muscle IGF-I independently modulates anabolism and metabolism in an age-dependent manner, thus positioning muscle IGF-I maintenance to be critical for both muscle growth and metabolic homeostasis.-Vassilakos, G., Lei, H., Yang, Y., Puglise, J., Matheny, M., Durzynska, J., Ozery, M., Bennett, K., Spradlin, R., Bonanno, H., Park, S., Ahima, R. S., Barton, E. R. Deletion of muscle IGF-I transiently impairs growth and progressively disrupts glucose homeostasis in male mice.

Indexed as

Body WeightExercise ToleranceHomeostasisAnimalsFemaleGlucoseInsulin-Like Growth Factor IMaleMiceMice, KnockoutMuscle ProteinsMuscle, SkeletalPhysical Conditioning, AnimalSignal TransductionSKP Cullin F-Box Protein LigasesFbxo32 protein, mouseGlucoseinsulin-like growth factor-1, mouseInsulin-Like Growth Factor IMuscle ProteinsSKP Cullin F-Box Protein Ligasesdiabetesexercise intoleranceforce generation

Identifiers

PMID29932867
PMCPMC6355069

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.