Evidence map›Paper›PMID 29932782›Full record

ArticleLeukemia & lymphoma2019

PARP1 inhibitor eliminated imatinib-refractory chronic myeloid leukemia cells in bone marrow microenvironment conditions.

Paulina Podszywalow-Bartnicka, Silvia Maifrede, Bac Viet Le, Margaret Nieborowska-Skorska, Katarzyna Piwocka, Tomasz Skorski

Abstract readLetter
In one paragraph

Article in Leukemia & lymphoma, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Paulina Podszywalow-Bartnickaa Temple University Lewis Katz School of Medicine , Department of Microbiology and Immunology and Fels Institute for Cancer Research & Molecular Biology , Philadelphia , PA , USA.
Silvia Maifredea Temple University Lewis Katz School of Medicine , Department of Microbiology and Immunology and Fels Institute for Cancer Research & Molecular Biology , Philadelphia , PA , USA.
Bac Viet Lea Temple University Lewis Katz School of Medicine , Department of Microbiology and Immunology and Fels Institute for Cancer Research & Molecular Biology , Philadelphia , PA , USA.
Margaret Nieborowska-Skorskaa Temple University Lewis Katz School of Medicine , Department of Microbiology and Immunology and Fels Institute for Cancer Research & Molecular Biology , Philadelphia , PA , USA.
Katarzyna Piwockab Laboratory of Cytometry , Nencki Institute of Experimental Biology , Warsaw , Poland.
Tomasz Skorskia Temple University Lewis Katz School of Medicine , Department of Microbiology and Immunology and Fels Institute for Cancer Research & Molecular Biology , Philadelphia , PA , USA.

Funding

Targeting DNA repair to eradicate TKi-refractory/resistant CML and Ph+ALLR01CA186238 · NCI · TEMPLE UNIV OF THE COMMONWEALTH · PI SKORSKI, TOMASZ · 2014 to 2024
$4.5M
NCI NIH HHS R01 CA186238
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsAntineoplastic Combined Chemotherapy ProtocolsBone Marrow CellsCell Line, TumorCoculture TechniquesDNA Breaks, Double-StrandedDrug Resistance, NeoplasmHumansImatinib MesylateLeukemia, Myelogenous, Chronic, BCR-ABL PositiveMiceNeoplastic Stem CellsPhthalazinesPoly (ADP-Ribose) Polymerase-1Tumor MicroenvironmentXenograft Model Antitumor AssaysImatinib MesylatePARP1 protein, humanPhthalazinesPoly (ADP-Ribose) Polymerase-1talazoparib

Identifiers

PMID29932782
PMCPMC6309580

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.