ArticleInternational journal for numerical methods in biomedical engineering2018
Influence of ageing on human body blood flow and heat transfer: A detailed computational modelling study.
Article in International journal for numerical methods in biomedical engineering, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 28 citations in OpenAlex.
- Human simulation model for predicting body temperature, blood pressure, and blood flow rate under various thermal exposures - Part 1: development of physical model for average Japanese male in their 20s.International journal of biometeorology · 2026Article
- Developing cardiac biomechanical models beyond the clinic: modeling stressors of daily life.Biomechanics and modeling in mechanobiology · 2025Review
- Biophysical versus machine learning models for predicting rectal and skin temperatures in older adults.Journal of thermal biology · 2025Article
- Quantitative analysis of systemic perfusion and cerebral blood flow in the modeling of aging and orthostatic hypotension.Frontiers in physiology · 2024Article
- Arterial pulse wave modeling and analysis for vascular-age studies: a review from VascAgeNet.American journal of physiology. Heart and circulatory physiology · 2023Review
- Modeling Reactive Hyperemia to Better Understand and Assess Microvascular Function: A Review of Techniques.Annals of biomedical engineering · 2023Review
- A framework for incorporating 3D hyperelastic vascular wall models in 1D blood flow simulations.Biomechanics and modeling in mechanobiology · 2021Article
- Modeling arterial pulse waves in healthy aging: a database for in silico evaluation of hemodynamics and pulse wave indexes.American journal of physiology. Heart and circulatory physiology · 2019Article
- A novel porous media-based approach to outflow boundary resistances of 1D arterial blood flow models.Biomechanics and modeling in mechanobiology · 2019Article
- Influence of ageing on human body blood flow and heat transfer: A detailed computational modelling study.International journal for numerical methods in biomedical engineering · 2018Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Ageing plays a fundamental role in arterial blood transport and heat transfer within a human body. The aim of this work is to provide a comprehensive methodology, based on biomechanical considerations, for modelling arterial flow and energy exchange mechanisms in the body accounting for age-induced changes. The study outlines a framework for age-related modifications within several interlinked subsystems, which include arterial stiffening, heart contractility variations, tissue volume and property changes, and thermoregulatory system deterioration. Some of the proposed age-dependent governing equations are directly extrapolated from experimental data sets. The computational framework is demonstrated through numerical experiments, which show the impact of such age-related changes on arterial blood pressure, local temperature distribution, and global body thermal response. The proposed numerical experiments show that the age-related changes in arterial convection do not significantly affect the tissue temperature distribution. Results also highlight age-related effects on the sweating mechanism, which lead to a significant reduction in heat dissipation and a subsequent rise in skin and core temperatures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.