Evidence map›Paper›PMID 29932437›Full record

ArticleInternational journal of molecular sciences2018

Receptor Activator of Nuclear Factor Kappa B (RANK) and Clinicopathological Variables in Endometrial Cancer: A Study at Protein and Gene Level.

Raúl Gómez, Ana Castro, Jessica Martínez, Víctor Rodríguez-García, Octavio Burgués, Juan J Tarín, Antonio Cano

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Raúl GómezResearch Unit on Women's Health-Institute of Health Research INCLIVA, 46010 Valencia, Spain. raulgomgal@gmail.com.
Ana CastroDepartment of Pediatrics, Obstetrics and Gynecology, University of Valencia, 46010 Valencia, Spain. anacastroperez1986@gmail.com.
Jessica MartínezResearch Unit on Women's Health-Institute of Health Research INCLIVA, 46010 Valencia, Spain. jmartinez@incliva.es.
Víctor Rodríguez-GarcíaResearch Unit on Women's Health-Institute of Health Research INCLIVA, 46010 Valencia, Spain. victor.rodriguez-garcia@uv.es.ORCID 0000-0002-1642-7637
Octavio BurguésPathology Department, Hospital Clinico Universitario, 46010 Valencia, Spain. octavio.burgues@uv.es.
Juan J TarínDepartment of Cellular Biology, Functional Biology and Physical Anthropology, University of Valencia, 46100 Burjassot, Spain. Juan.J.Tarin@uv.es.
Antonio CanoResearch Unit on Women's Health-Institute of Health Research INCLIVA, 46010 Valencia, Spain. antonio.cano@uv.es.
INCLIVA Health Research Institute · ESUniversitat de València · ESHospital Clínico Universitario de Valencia · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The system integrated by the receptor activator of nuclear factor kappa B (RANK) and its ligand, RANKL, modulates the role of hormones in the genesis and progression of breast tumors. We investigated whether the expression of RANK was related with clinicopathological features of primary endometrial tumors. Immunohistochemistry was used in an endometrial cancer tissue array containing samples from 36 tumors. The amount of RANK mRNA was examined in a tissue scan cDNA array containing cDNA from 40 tumors. Normal endometrium was examined for comparison. Immunohistochemical analyses showed that RANK expression was higher in malignant than in normal endometrium (

Indexed as

Gene Expression Regulation, NeoplasticAdenocarcinomaAdultAlternative SplicingEndometrial NeoplasmsEndometriumFemaleHumansImmunohistochemistryMiddle AgedNeoplasm GradingNeoplasm StagingProtein IsoformsReceptor Activator of Nuclear Factor-kappa BRNA, MessengerTissue Array AnalysisProtein IsoformsReceptor Activator of Nuclear Factor-kappa BRNA, MessengerTNFRSF11A protein, humanendometrial cancerendometriumgene expressionimmunohistochemistryprognosisRANK

Identifiers

PMID29932437
PMCPMC6073139
OpenAlexW2809296657

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.