ArticleCancer medicine2018
Trends in colorectal cancer incidence among younger adults-Disparities by age, sex, race, ethnicity, and subsite.
Article in Cancer medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Fecal Microbiome Alterations in Colorectal Cancer: A Systematic Review of Compositional Changes and Microbial Biomarkers.MicrobiologyOpen · 2026Pooled it
- A systematic review of methods to estimate colorectal cancer incidence using population-based cancer registries.BMC medical research methodology · 2022Pooled it
- Statistical methods for measuring trends in colorectal cancer incidence in registries: A systematic review.Frontiers in oncology · 2022Pooled it
- Trends in the epidemiology of young-onset colorectal cancer: a worldwide systematic review.BMC cancer · 2020Pooled it
- A qualitative study of a new metric for estimating early-onset colorectal cancer risk in male veterans: "Colon Age".BMC primary care · 2025Article
- Sex and age-related differences in one-, three-, and five-year survival for early-onset colorectal cancer in Georgia.American journal of cancer research · 2025Article
- Identification of Gut Microbiota Profile Associated with Colorectal Cancer in Saudi Population.Cancers · 2023Article
- The diet-microbiota axis: a key regulator of intestinal permeability in human health and disease.Tissue barriers · 2023Review
- History of colonoscopy and technological advances: a narrative review.Translational gastroenterology and hepatology · 2023Review
- A Transcriptome and Methylome Study Comparing Tissues of Early and Late Onset Colorectal Carcinoma.International journal of molecular sciences · 2022Article
- Global, regional, and national burden of colorectal cancer and its risk factors, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019.The lancet. Gastroenterology & hepatology · 2022Article
- Early-onset colorectal cancer: why it should be high on our list of differentials.ANZ journal of surgery · 2022Review
- Incidence trends for twelve cancers in younger adults-a rapid review.British journal of cancer · 2022Review
- New considerations for colorectal cancer screening based on the demographic profile of colorectal cancer in a Greek population.Molecular and clinical oncology · 2022Article
- Emerging trends in colorectal cancer: Dysregulated signaling pathways (Review).International journal of molecular medicine · 2021Article
- Colorectal cancer incidence and mortality trends by sex and population group in South Africa: 2002-2014.BMC cancer · 2021Article
- Colorectal Cancer Screening Prevalence and Adherence for the Cancer Prevention Project of Philadelphia (CAP3) Participants Who Self-Identify as Black.Frontiers in oncology · 2021Article
- Trends in Colorectal Cancer Incidence Rates in Saudi Arabia (2001-2016) Using Saudi National Registry: Early- Versus Late-Onset Disease.Frontiers in oncology · 2021Article
- Increasing Rates of Colorectal Cancer Among Young People in California, 1988-2017.Journal of registry management · 2021Article
- Rectal cancer in young patients: incidence and outcome disparities.Journal of gastrointestinal oncology · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Millennials (ages 18-35) are now the largest living generation in the US, making it important to understand and characterize the rising trend of colorectal cancer incidence in this population, as well as other younger generations of Americans. Data from the New Jersey State Cancer Registry (n = 181 909) and Surveillance, Epidemiology, and End Results program (n = 448 714) were used to analyze invasive CRC incidence trends from 1979 to 2014. Age, sex, race, ethnicity, subsite, and stage differences between younger adults (20-49) and screening age adults (≥50) in New Jersey (NJ) were examined using chi-square; and, we compared secular trends in NJ to the United States (US). Whites, men, and the youngest adults (ages 20-39) are experiencing greater APCs in rectal cancer incidence. Rates among younger black adults, overall, were consistently higher in both NJ and the US over time. When compared to older adults, younger adults with CRC in NJ were more likely to be: diagnosed at the late stage, diagnosed with rectal cancer, male, non-white, and Hispanic. Invasive CRC incidence trends among younger adults were found to vary by age, sex, race, ethnicity, and subsite. Large, case-level, studies are needed to understand the role of genetics, human papillomavirus (HPV), and cultural and behavioral factors in the rise of CRC among younger adults. Provider and public education about CRC risk factors will also be important for preventing and reversing the increasing CRC trend in younger adults.
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