ArticleJournal of genetics2018
Dosage effects in morphogenetic gradients of transcription factors: insights from a simple mathematical model.
Article in Journal of genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Unraveling cis and trans regulatory evolution during cotton domestication.Nature communications · 2019Article
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Authors and funding
1 author.
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Abstract
The classical Hill equation is the simplest way to model sharp transcriptional responses (TR) to changing concentrations of a regulator. Such steep sigmoidal transitions of the TR are often involved in the creation of boundaries or domains during development. Here, I use the Hill function to explore the response of a promoter to a gradient of a transcription factor (TF). Specifically, I examine how various sources of nonlinearity (such as that imposed by the number of TF-binding sites) and the nonlinearity of the gradient itself influence TR and modulate its robustness to variations in the dosage of morphogen. This qualitative analysis underscores how nonlinearities can modulate the robustness of TR and is a convenient way to convey concepts in a teaching setting.
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Registered trials
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