Evidence map›Paper›PMID 29932046›Full record

ReviewDeutsches Arzteblatt international2018

Chronic Headache Due to Overuse of Analgesics and Anti-Migraine Agents.

Hans-Christoph Diener, Dagny Holle, Thomas Dresler, Charly Gaul

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Deutsches Arzteblatt international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  10. Medication overuse headache: a review of current evidence and management strategies.Frontiers in pain research (Lausanne, Switzerland) · 2023
    Review
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  18. In Reply.Deutsches Arzteblatt international · 2018
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  19. Causes Need to Be Comprehensively Investigated.Deutsches Arzteblatt international · 2018
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Hans-Christoph DienerDepartment of Neurology and West German Headache Center, Essen; Department of Neurology and West German Headache Center, Essen; Department of Psychiatry and Psychotherapy, University Hospital and Faculty of Medicine, Tübingen; LEAD Graduate School & Research Network, University of Tübingen; Migraine and Headache Clinic Königstein.
Dagny Holle
Thomas Dresler
Charly Gaul

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe frequent or regular use of analgesics and anti-migraine drugs can make headache more frequent and induce the transformation of episodic to chronic headache. Chronic headache due to medication overuse is defined as headache that is present on ≥ 15 days per month for at least three months in a patient who previously suffered from primary headaches, and who takes analgesics on ≥ 15 days per month or anti-migraine drugs (triptans or ergot alkaloids), opioid drugs, or combined analgesics on ≥ 10 days per month.

methodsThis review is based on pertinent articles published up to December 2017 that were retrieved by a selective search in PubMed employing the terms "medication overuse AND headache" and "medication overuse headache."

resultsThe prevalence of medication overuse headache in the general population in Germany is 0.7% -1%. This disorder is more common in women and in persons suffering from comorbid mental disorders or other painful conditions. The treatment of medication overuse headache consists of three steps. Patient education and counseling are given with the goal of reducing the intake of medication for acute headache treatment. The ensuing headache prophylaxis is with topiramate, amitriptyline, or onabotulinum toxin A. If these treatment strategies fail, a drug holiday is recommended. This can be in the outpatient, day clinic, or inpatient setting, depending on the severity of the condition and its comorbidities.

conclusionPatients who frequently take acute medication to treat headache episodes must be identified early in order to avoid headache chronification and medication overuse headache. The suggested treatment algorithm is still in need of validation by randomized trials.

Indexed as

Headache Disorders, SecondaryAge FactorsAnalgesicsFemaleGermanyHumansMaleSerotonin Receptor AgonistsSex FactorsAnalgesicsSerotonin Receptor Agonists

Identifiers

PMID29932046
PMCPMC6039717

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.