ReviewMicrobiology spectrum2018
Optimization of Antimicrobial Treatment to Minimize Resistance Selection.
Review in Microbiology spectrum, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed.
- Generation of equine-specific local antibiograms: reproductive tract of mares and fillies in Western Australia.Australian veterinary journal · 2026Article
- Covalent Inhibitors in Antimicrobial Drug Development-Beyond β-Lactams.Molecules (Basel, Switzerland) · 2026Review
- Cross-sectional study of calves from Norwegian dairy herds with enzootic pneumonia: pathogen occurrence, antimicrobial resistance, culture result interpretation, and sampling site agreement.BMC veterinary research · 2026Article
- Faecal microbiome profiling uncovers putative biomarkers for piglets resilient to post-weaning diarrhoea.Animal microbiome · 2026Article
- A Systematic Review of Bacterial Sampling Collection for Veterinary Microbiology in Companion Animals.Veterinary sciences · 2026Review
- Cross-sectional study of calves from Norwegian fattening herds with enzootic pneumonia: pathogen occurrence, clinical relevance, antimicrobial resistance, and agreement between respiratory tract sampling sites.Frontiers in veterinary science · 2026Article
- European Network for Optimization of Veterinary Antimicrobial Therapy (ENOVAT) guidelines for antimicrobial and non-steroidal anti-inflammatory drug use in bovine respiratory disease.Open research Europe · 2026Article
- Antimicrobial Use and Awareness of Antimicrobial Resistance in the Livestock Sector in the Western Balkans.Antibiotics (Basel, Switzerland) · 2025Article
- Risk of multidrug resistance in Escherichia coli associated with routine antimicrobial prophylaxis on pig farms.npj antimicrobials and resistance · 2025Article
- Evaluation of the performance of topical products containing Ophytrium and chlorhexidine digluconate in cats with local cutaneous bacterial and/orJournal of feline medicine and surgery · 2025Article
- Article
- Use of Subtherapeutic Tylvalosin AgainstTransboundary and emerging diseases · 2025Article
- A qualitative content analysis exploring the portrayal of antibiotic use and antibiotic resistance in UK smallholding print media.Frontiers in veterinary science · 2025Article
- Enhancing antibiotic therapy through comprehensive pharmacokinetic/pharmacodynamic principles.Frontiers in cellular and infection microbiology · 2025Review
- Article
- Effect of single parenteral administration of marbofloxacin on bacterial load and selection of resistant Enterobacteriaceae in the fecal microbiota of healthy pigs.BMC veterinary research · 2024Article
- How Restrictive Legislation Influences Antimicrobial Susceptibility in Selected Bacterial Isolates from the Canine Vagina.Antibiotics (Basel, Switzerland) · 2024Article
- Dairy farmer, engagement and understanding of One Health and antimicrobial resistance - a pilot survey from the lower north island of Aotearoa New Zealand.One health outlook · 2024Article
- Reducing Improper and Missed Peri-Procedure Antibiotics Prescriptions in a Regional Oncology Centre.Cureus · 2024Article
- Online-Assisted Survey on Antibiotic Use by Pet Owners in Dogs and Cats.Antibiotics (Basel, Switzerland) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Optimization of antimicrobial treatment is a cornerstone in the fight against antimicrobial resistance. Various national and international authorities and professional veterinary and farming associations have released generic guidelines on prudent antimicrobial use in animals. However, these generic guidelines need to be translated into a set of animal species- and disease-specific practice recommendations. This article focuses on prevention of antimicrobial resistance and its complex relationship with treatment efficacy, highlighting key situations where the current antimicrobial drug products, treatment recommendations, and practices may be insufficient to minimize antimicrobial selection. The authors address this topic using a multidisciplinary approach involving microbiology, pharmacology, clinical medicine, and animal husbandry. In the first part of the article, we define four key targets for implementing the concept of optimal antimicrobial treatment in veterinary practice: (i) reduction of overall antimicrobial consumption, (ii) improved use of diagnostic testing, (iii) prudent use of second-line, critically important antimicrobials, and (iv) optimization of dosage regimens. In the second part, we provided practice recommendations for achieving these four targets, with reference to specific conditions that account for most antimicrobial use in pigs (intestinal and respiratory disease), cattle (respiratory disease and mastitis), dogs and cats (skin, intestinal, genitourinary, and respiratory disease), and horses (upper respiratory disease, neonatal foal care, and surgical infections). Lastly, we present perspectives on the education and research needs for improving antimicrobial use in the future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.